Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Youngjo | - |
dc.contributor.author | Bayona, Princess Wendy | - |
dc.contributor.author | Kim, Miri | - |
dc.contributor.author | Chang, Jiyeon | - |
dc.contributor.author | Hong, Sunmin | - |
dc.contributor.author | Park, Yoona | - |
dc.contributor.author | Budiman, Andrea | - |
dc.contributor.author | Kim, Yong-Jin | - |
dc.contributor.author | Choi, Chang Yong | - |
dc.contributor.author | Kim, Woo Seok | - |
dc.contributor.author | Lee, Jongsoon | - |
dc.contributor.author | Cho, Kae Won | - |
dc.date.accessioned | 2021-08-11T12:24:08Z | - |
dc.date.available | 2021-08-11T12:24:08Z | - |
dc.date.issued | 2018-04-20 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6039 | - |
dc.description.abstract | Obesity-induced chronic low-grade inflammation, in particular in adipose tissue, contributes to the development of insulin resistance and type 2 diabetes. However, the mechanism by which obesity induces adipose tissue inflammation has not been completely elucidated. Recent studies suggest that alteration of the nuclear lamina is associated with age-associated chronic inflammation in humans and fly. These findings led us to investigate whether the nuclear lamina regulates obesity-mediated chronic inflammation. In this study, we show that lamin A/C mediates inflammation in macrophages. The gene and protein expression levels of lamin A/C are significantly increased in epididymal adipose tissues from obese rodent models and omental fat from obese human subjects compared to their lean controls. Flow cytometry and gene expression analyses reveal that the protein and gene expression levels of lamin A/C are increased in adipose tissue macrophages (ATMs) by obesity. We further show that ectopic overexpression of lamin A/C in macrophages spontaneously activates NF-kappa B, and increases the gene expression levels of proinflammatory genes, such as Il6, Tnf, Ccl2, and Nos2. Conversely, deletion of lamin A/C in macrophages reduces LPS-induced expression of these proinflammatory genes. Importantly, we find that myeloid cell-specific lamin A/C deficiency ameliorates obesity-induced insulin resistance and adipose tissue inflammation. Thus, our data suggest that lamin A/C mediates the activation of ATM inflammation by regulating NF-kappa B, thereby contributing to the development of obesity-induced insulin resistance. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Frontiers Media S.A. | - |
dc.title | Macrophage Lamin A/C Regulates Inflammation and the Development of Obesity-Induced Insulin Resistance | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.3389/fimmu.2018.00696 | - |
dc.identifier.scopusid | 2-s2.0-85045724616 | - |
dc.identifier.wosid | 000430500800001 | - |
dc.identifier.bibliographicCitation | Frontiers in Immunology, v.9 | - |
dc.citation.title | Frontiers in Immunology | - |
dc.citation.volume | 9 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE MACROPHAGES | - |
dc.subject.keywordPlus | GENOME-WIDE SEARCH | - |
dc.subject.keywordPlus | NUCLEAR-ENVELOPE | - |
dc.subject.keywordPlus | SUSCEPTIBILITY GENES | - |
dc.subject.keywordPlus | METABOLIC SYNDROME | - |
dc.subject.keywordPlus | COMMON VARIATION | - |
dc.subject.keywordPlus | STEM-CELLS | - |
dc.subject.keywordPlus | ASSOCIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | LMNA | - |
dc.subject.keywordAuthor | lamin A/C | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordAuthor | insulin resistance | - |
dc.subject.keywordAuthor | macrophages | - |
dc.subject.keywordAuthor | adipose tissue | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.