Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1
DC Field | Value | Language |
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dc.contributor.author | Kim, Ah-Yeon | - |
dc.contributor.author | Shim, Hyun-Jin | - |
dc.contributor.author | Shin, Hyeon-Myeong | - |
dc.contributor.author | Lee, Yoo Jung | - |
dc.contributor.author | Nam, Hyeonjeong | - |
dc.contributor.author | Kim, Su Yeon | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-11T12:24:16Z | - |
dc.date.available | 2021-08-11T12:24:16Z | - |
dc.date.issued | 2018-04 | - |
dc.identifier.issn | 1567-5769 | - |
dc.identifier.issn | 1878-1705 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6078 | - |
dc.description.abstract | Toll-like receptors (TLRs) play a crucial role in danger recognition and induction of innate immune response against bacterial and viral infections. The TLR adaptor molecule, toll-interleuidn-1 receptor domain-containing adapter inducing interferon-beta (TRW), facilitates TLR3 and TLR4 signaling, leading to the activation of the transcription factor, NF-kappa B and interferon regulatory factor 3 (IRF3). Andrographolide, the active component of Andivgraphis paniculata, exerts anti-inflammatory effects; however, the principal molecular mechanisms remain unclear. The objective of this study was to investigate the role of andrographolide in TLR signaling pathways. Andrographolide suppressed NF-kappa B activation as well as COX-2 expression induced by TLR3 or TLR4 agonists. Andrographolide also suppressed the activation of IRF3 and the expression of interferon inducible protein-10 (IP-10) induced by TLR3 or TLR4 agonists. Andrographolide attenuated ligand-independent activation of IRF3 following overexpression of TRIP, TBK1, or IRF3. Furthermore, andrographolide inhibited TBK1 ldnase activity in vitro. These results indicate that andrographolide modulates the TRIP-dependent pathway of TLR5 by targeting TBK1 and represents a potential new anti-inflammatory candidate. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1 | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.intimp.2018.02.019 | - |
dc.identifier.scopusid | 2-s2.0-85045754632 | - |
dc.identifier.wosid | 000430768100021 | - |
dc.identifier.bibliographicCitation | International Immunopharmacology, v.57, pp 172 - 180 | - |
dc.citation.title | International Immunopharmacology | - |
dc.citation.volume | 57 | - |
dc.citation.startPage | 172 | - |
dc.citation.endPage | 180 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | LIPOPOLYSACCHARIDE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordAuthor | Toll-like receptors | - |
dc.subject.keywordAuthor | Andrographolide | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | TRIF | - |
dc.subject.keywordAuthor | TBK1 | - |
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