Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chung, Man P. | - |
dc.contributor.author | Nam, Bo D. | - |
dc.contributor.author | Lee, Kyung S. | - |
dc.contributor.author | Han, Joungho | - |
dc.contributor.author | Park, Jai S. | - |
dc.contributor.author | Hwang, Jung H. | - |
dc.contributor.author | Cha, Min J. | - |
dc.contributor.author | Kim, Tae J. | - |
dc.date.accessioned | 2021-08-11T12:43:37Z | - |
dc.date.available | 2021-08-11T12:43:37Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1323-7799 | - |
dc.identifier.issn | 1440-1843 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6189 | - |
dc.description.abstract | Background and objectiveCryptogenic organizing pneumonia (COP) is corticosteroid responsive but residual computed tomography (CT) chest changes are often noted. The present study examined clinical and HRCT features of COP in which there was incomplete resolution. MethodsWe studied 93 patients with histopathologically confirmed COP and serial HRCT imaging. Clinical features were assessed, and serial CT images were analysed. Uni- and multivariate analyses were performed to determine clinical or imaging factors related to incomplete resolution on CT. ResultsComplete resolution on CT imaging was seen in 21/93 patients (23%) and residual abnormalities were seen in 72/93 patients (77%). In univariate analysis, total lesion (P=0.036), degree of consolidation (P=0.011), treatment duration (P<0.001) and single-breath carbon monoxide diffusing capacity of lung (P=0.021) were significantly associated with residual imaging abnormalities. In multivariate analysis, extent of consolidation (P=0.018; odds ratio (OR)=14.92) and treatment duration (P=0.011; OR=1.32) remained as significant factors linked to residual abnormalities. CT images in unresolved COP were akin to fibrotic non-specific interstitial pneumonia (fNSIP) in 53/72 (74%) patients. ConclusionClinical, radiological and lung diffusion measurements were related to incomplete resolution on CT after COP. Imaging abnormalities on CT chest generally resembled fNSIP. In patients with cryptogenic organizing pneumonia, 77% had residual computed tomography (CT) abnormalities on follow-up CT chest, even after corticosteroid treatment. The extent of lung abnormalities, consolidation on CT, diffusion measurements and treatment duration were factors associated with residual CT abnormalities. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Serial chest CT in cryptogenic organizing pneumonia: Evolutional changes and prognostic determinants | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/resp.13188 | - |
dc.identifier.scopusid | 2-s2.0-85042095139 | - |
dc.identifier.wosid | 000425143600016 | - |
dc.identifier.bibliographicCitation | Respirology, v.23, no.3, pp 325 - 330 | - |
dc.citation.title | Respirology | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 325 | - |
dc.citation.endPage | 330 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | BRONCHIOLITIS OBLITERANS | - |
dc.subject.keywordPlus | INTERSTITIAL PNEUMONIA | - |
dc.subject.keywordPlus | FEATURES | - |
dc.subject.keywordPlus | LUNG | - |
dc.subject.keywordAuthor | computed tomography chest | - |
dc.subject.keywordAuthor | cryptogenic organizing pneumonia | - |
dc.subject.keywordAuthor | interstitial lung disease | - |
dc.subject.keywordAuthor | non-specific interstitial pneumonia | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.