Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus
DC Field | Value | Language |
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dc.contributor.author | Lee, Jae-Chul | - |
dc.contributor.author | Kim, In Hye | - |
dc.contributor.author | Cho, Jeong Hwi | - |
dc.contributor.author | Lee, Tae-Kyeong | - |
dc.contributor.author | Park, Joon Ha | - |
dc.contributor.author | Ahn, Ji Hyeon | - |
dc.contributor.author | Shin, Bich Na | - |
dc.contributor.author | Yan, Bing Chun | - |
dc.contributor.author | Kim, Jong-Dai | - |
dc.contributor.author | Jeon, Yong Hwan | - |
dc.contributor.author | Lee, Young Joo | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.contributor.author | Kang, Il Jun | - |
dc.date.accessioned | 2021-08-11T12:43:38Z | - |
dc.date.available | 2021-08-11T12:43:38Z | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.issn | 1791-3004 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6197 | - |
dc.description.abstract | 4-Hydroxy-3-methoxybenzaldehyde (vanillin), contained in a number of species of plant, has been reported to display beneficial effects against brain injuries. In the present study, the impact of vanillin on scopolamine-induced alterations in cognition and the expression of DNA binding protein inhibitor ID-1 (ID1), one of the inhibitors of DNA binding/differentiation proteins that regulate gene transcription, in the mouse hippocampus. Mice were treated with 1 mg/kg scopolamine with or without 40 mg/kg vanillin once daily for 4 weeks. Scopolamine-induced cognitive impairment was observed from 1 week and was deemed to be severe 4 weeks following the administration of scopolamine. However, treatment with vanillin in scopolamine-treated mice markedly attenuated cognitive impairment 4 weeks following treatment with scopolamine. ID1-immunoreactive cells were revealed in the hippocampus of vehicle-treated mice, and were hardly detected 4 weeks following treatment with scopolamine. However, treatment with vanillin in scopolamine-treated mice markedly restored ID1-immunoreactive cells and expression 4 weeks subsequent to treatment. The results of the present study suggested that vanillin may be beneficial for cognitive impairment, by preventing the reduction of ID1 expression which may be associated with cognitive impairment. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Spandidos Publications | - |
dc.title | Vanillin improves scopolamine-induced memory impairment through restoration of ID1 expression in the mouse hippocampus | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/mmr.2018.8401 | - |
dc.identifier.wosid | 000424400000123 | - |
dc.identifier.bibliographicCitation | Molecular Medicine Reports, v.17, no.3, pp 4399 - 4405 | - |
dc.citation.title | Molecular Medicine Reports | - |
dc.citation.volume | 17 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 4399 | - |
dc.citation.endPage | 4405 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | MUSCARINIC ACETYLCHOLINE-RECEPTORS | - |
dc.subject.keywordPlus | LOOP-HELIX PROTEINS | - |
dc.subject.keywordPlus | NEURAL STEM-CELLS | - |
dc.subject.keywordPlus | DORSAL HIPPOCAMPUS | - |
dc.subject.keywordPlus | GABAERGIC NEURONS | - |
dc.subject.keywordPlus | GASTRODIA-ELATA | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | WATER-MAZE | - |
dc.subject.keywordPlus | NEUROGENESIS | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordAuthor | muscarinic acetylcholine receptor | - |
dc.subject.keywordAuthor | cholinergic transmission | - |
dc.subject.keywordAuthor | cognitive deficits | - |
dc.subject.keywordAuthor | DNA binding protein inhibitor | - |
dc.subject.keywordAuthor | 4-hydroxy-3-methoxybenzaldehyde | - |
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