Olfactory dysfunctions in drug-naive Parkinson's disease with mild cognitive impairment
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Jin-Woo | - |
dc.contributor.author | Kwon, Do-Young | - |
dc.contributor.author | Choi, Ji Ho | - |
dc.contributor.author | Park, Moon-Ho | - |
dc.contributor.author | Yoon, Ho-Kyoung | - |
dc.date.accessioned | 2021-08-11T12:43:59Z | - |
dc.date.available | 2021-08-11T12:43:59Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1353-8020 | - |
dc.identifier.issn | 1873-5126 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6316 | - |
dc.description.abstract | Background: Evaluation of olfactory function is valuable for the detection of pre-motor state of Parkinson's disease (PD). PD patients have an increased risk of associated dementia and one-third of PP patients have mild cognitive impairment (MCI) at the time of diagnosis. However, the characteristics of olfactory dysfunction in PD-MCI patients are unclear. This study examined the relationship between olfactory dysfunction and cognitive function in drug-naive PD at the time of diagnosis with the patterns of olfactory function in PD-MCI patients using the Korean version of the Sniffin' stick test II (KVSS II). Methods: A total of 66 drug-naive PD patients were enrolled. A neuropsychiatric assessment battery and KVSS II were performed. For the statistical analyses, univariate, multivariable linear regression and Student's t-test were used to determine the relationship between the variables and olfactory function. Results: Olfactory dysfunction was more prevalent in the PD-MCI group than in the PD-normal cognition (PD-CN) group. Each domains of odor threshold, discrimination, identification and total olfactory score were more impaired in the PD-MCI group than the PD-CN group. Whether cognitive impairment was single or multiple domain was not affected. Conclusion: PD-MCI is more likely to be associated with severe olfactory impairment than PD-CN. There may be more extensive neurodegenerative processes affecting olfaction in PD-MCI patients. With further investigation and validation using neuropathological data, an objective olfactory function test could be used as a tool to evaluate disease progression. Further studies with prospective design investigating the prognostic value of olfactory dysfunction in PD-MCI patients are essential. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Olfactory dysfunctions in drug-naive Parkinson's disease with mild cognitive impairment | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.parkreldis.2017.11.334 | - |
dc.identifier.scopusid | 2-s2.0-85040111617 | - |
dc.identifier.wosid | 000419811800013 | - |
dc.identifier.bibliographicCitation | Parkinsonism and Related Disorders, v.46, pp 69 - 73 | - |
dc.citation.title | Parkinsonism and Related Disorders | - |
dc.citation.volume | 46 | - |
dc.citation.startPage | 69 | - |
dc.citation.endPage | 73 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | DIAGNOSTIC-CRITERIA | - |
dc.subject.keywordPlus | KOREAN VERSION | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordAuthor | Mild cognitive impairment | - |
dc.subject.keywordAuthor | Parkinson's disease | - |
dc.subject.keywordAuthor | Olfactory dysfunction | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.