Effects of long-term scopolamine treatment on cognitive deficits and calcium binding proteins immunoreactivities in the mouse hippocampus
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ahn, Ji Hyeon | - |
dc.contributor.author | Chen, Bai Hui | - |
dc.contributor.author | Yan, Bing Chun | - |
dc.contributor.author | Park, Joon Ha | - |
dc.contributor.author | Kang, Il Jun | - |
dc.contributor.author | Lee, Tae-Kyeong | - |
dc.contributor.author | Cho, Jeong Hwi | - |
dc.contributor.author | Shin, Bich-Na | - |
dc.contributor.author | Lee, Jae-Chul | - |
dc.contributor.author | Jeon, Yong Hwan | - |
dc.contributor.author | Hong, Seongkweon | - |
dc.contributor.author | Lee, Young Joo | - |
dc.contributor.author | Choi, Soo Young | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.date.accessioned | 2021-08-11T12:44:00Z | - |
dc.date.available | 2021-08-11T12:44:00Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 1791-2997 | - |
dc.identifier.issn | 1791-3004 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6320 | - |
dc.description.abstract | GABAergic projections terminate on numerous hippocampal interneurons containing calcium binding proteins (CBPs), including calbindin D-28k (CB), calretinin (CR) and parvalbumin (PV). Memory deficits and expression levels of CB, CR, and PV were examined in the hippocampal subregions following systemic scopolamine (Scop; 1 mg/kg) treatment for 4 weeks in mice. Scop treatment induced significant memory deficits from 1 week after Scop treatment. CB, CR and PV immunoreactivities distributions were in hippocampal subregions [CA1 and CA3 regions, and the dentate gyrus (DG)]. CB immunoreactivity (CB+) was gradually decreased in all subregions until 2 weeks after Scop treatment, and CB+ was decreased to the lowest level in all subregions at 3 and 4 weeks. CR+ in the CA1 region was gradually decreased until 2 weeks and hardly observed at 3 and 4 weeks; in the CA3 region, CR+ was not altered in all subregions at any time. In the DG, CR+ was gradually decreased until 2 weeks and lowest at 3 and 4 weeks. PV+ in the CA1 region was not altered at 1 week, and gradually decreased from 2 weeks. In the CA3 region, PV+ did not change in any subregions at any time. In the DG, PV+ was not altered at 1 week, decreased at 2 weeks, and lowest at 3 and 4 weeks. In brief, Scop significantly decreased CBPs expressions in the hippocampus 3 weeks after the treatment although memory deficits had developed at 1 week. Therefore, it is suggested that Scop (1 mg/kg) must be systemically treated for 3 weeks to investigate changes in expression levels of CBPs in the hippocampus. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Spandidos Publications | - |
dc.title | Effects of long-term scopolamine treatment on cognitive deficits and calcium binding proteins immunoreactivities in the mouse hippocampus | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.doi | 10.3892/mmr.2017.7928 | - |
dc.identifier.wosid | 000423433300036 | - |
dc.identifier.bibliographicCitation | Molecular Medicine Reports, v.17, no.1, pp 293 - 299 | - |
dc.citation.title | Molecular Medicine Reports | - |
dc.citation.volume | 17 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 293 | - |
dc.citation.endPage | 299 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | MUSCARINIC ACETYLCHOLINE-RECEPTORS | - |
dc.subject.keywordPlus | SEPTOHIPPOCAMPAL GABA | - |
dc.subject.keywordPlus | GERBIL HIPPOCAMPUS | - |
dc.subject.keywordPlus | GABAERGIC NEURONS | - |
dc.subject.keywordPlus | WORKING-MEMORY | - |
dc.subject.keywordPlus | DENTATE GYRUS | - |
dc.subject.keywordPlus | AGED MICE | - |
dc.subject.keywordPlus | PARVALBUMIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | SCHIZOPHRENIA | - |
dc.subject.keywordAuthor | scopolamine | - |
dc.subject.keywordAuthor | memory impairments | - |
dc.subject.keywordAuthor | calcium binding proteins | - |
dc.subject.keywordAuthor | CA1-3 region | - |
dc.subject.keywordAuthor | dentate gyrus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.