Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma
DC Field | Value | Language |
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dc.contributor.author | Lee, Pureun-Haneul | - |
dc.contributor.author | Kim, Byeong-Gon | - |
dc.contributor.author | Lee, Sun-Hye | - |
dc.contributor.author | Lee, June-Hyuck | - |
dc.contributor.author | Park, Sung-Woo | - |
dc.contributor.author | Kim, Do-Jin | - |
dc.contributor.author | Park, Choon-Sik | - |
dc.contributor.author | Leikauf, George D. | - |
dc.contributor.author | Jane, An-Soo | - |
dc.date.accessioned | 2021-08-11T12:44:08Z | - |
dc.date.available | 2021-08-11T12:44:08Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 2092-7355 | - |
dc.identifier.issn | 2092-7363 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6358 | - |
dc.description.abstract | Purpose: Claudin-4 has been reported to function as a paracellular sodium barrier and is one of the 3 major claudins expressed in lung alveolar epithelia) cells. However, the possible role of claudin-4 in bronchial asthma has not yet been fully studied. In this study, we aimed to elucidate the role of claudin-4 in the pathogenesis of bronchial asthma. Methods: We determined claudin-4 levels in blood from asthmatic patients. Moreover, using mice sensitized and challenged with OVA, as well as sensitized and challenged with saline, we investigated whether claudin-4 is involved in the pathogenesis of bronchial asthma. Der p1 induced the inflammatory cytokines in NHBE cells. Results: We found that claudin-4 in blood from asthmatic patients was increased compared with that from healthy control subjects. Plasma claudin-4 levels were significantly higher in exacerbated patients than in control patients with bronchial asthma. The plasma claudin-4 level was correlated with eosinophils, total IgE, FEV1% pred, and FEV1/FVC. Moreover, lung tissues from the OVA-OVA mice showed significant increases in transcripts and proteins of claudin-4 as well as in TJ breaks and the densities of claudin-4 staining. When claudin-4 was knocked down by transfecting its siRNA, inflammatory cytokine expressions, which were induced by Der p1 treatment, were significantly increased. Conclusions: These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한천식알레르기학회 | - |
dc.title | Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4168/aair.2018.10.1.25 | - |
dc.identifier.scopusid | 2-s2.0-85038403154 | - |
dc.identifier.wosid | 000423419800006 | - |
dc.identifier.bibliographicCitation | Allergy, Asthma & Immunology Research, v.10, no.1, pp 25 - 33 | - |
dc.citation.title | Allergy, Asthma & Immunology Research | - |
dc.citation.volume | 10 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 25 | - |
dc.citation.endPage | 33 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002307733 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Allergy | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Allergy | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordPlus | EPITHELIAL BARRIER FUNCTION | - |
dc.subject.keywordPlus | TIGHT JUNCTIONS | - |
dc.subject.keywordPlus | LUNG INJURY | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | IMMUNITY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | epithelial barrier | - |
dc.subject.keywordAuthor | claudin-4 | - |
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