Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix
DC Field | Value | Language |
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dc.contributor.author | Kim, In Gul | - |
dc.contributor.author | Gil, Chang-Hyun | - |
dc.contributor.author | Seo, Joseph | - |
dc.contributor.author | Park, Soon-Jung | - |
dc.contributor.author | Subbiah, Ramesh | - |
dc.contributor.author | Jung, Taek-Hee | - |
dc.contributor.author | Kim, Jong Soo | - |
dc.contributor.author | Jeong, Young-Hoon | - |
dc.contributor.author | Chung, Hyung-Min | - |
dc.contributor.author | Lee, Jong Ho | - |
dc.contributor.author | Lee, Man Ryul | - |
dc.contributor.author | Moon, Sung-Hwan | - |
dc.contributor.author | Park, Kwideok | - |
dc.date.accessioned | 2021-08-11T12:44:12Z | - |
dc.date.available | 2021-08-11T12:44:12Z | - |
dc.date.issued | 2018-01 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.issn | 1878-5905 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6374 | - |
dc.description.abstract | Cell-derived matrices (CDM) are becoming an attractive alternative to conventional biological scaffolding platforms due to its unique ability to closely recapitulate a native extracellular matrix (ECM) de novo. Although cell-substrate interactions are recognized to be principal in regulating stem cell behavior, very few studies have documented the acclimation of human pluripotent stem cells (hPSCs) on pristine and altered cell-derived matrices. Here, we investigate crosslink-induced mechanotransduction of hPSCs cultivated on decellularized fibroblast-derived matrices (FDM) to explore cell, adhesion, growth, migration, and pluripotency in various biological landscapes. The results showed either substrate-mediated induction or inhibition of the Epithelial-Mesenchymal-Transition (EMT) program, strongly suggesting that FDM stiffness can be a dominant factor in mediating hPSC plasticity. We further propose an optimal FDM substratum intended for long-term hPSC cultivation in a feeder-free niche-like microenvironment. This study carries significant implications for hPSC cultivation and encourages more in-depth studies towards the fundamentals of hPSC-CDM interactions. (C) 2017 Elsevier Ltd. All rights reserved. | - |
dc.format.extent | 12 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Pergamon Press Ltd. | - |
dc.title | Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1016/j.biomaterials.2017.10.016 | - |
dc.identifier.scopusid | 2-s2.0-85031111577 | - |
dc.identifier.wosid | 000415781900008 | - |
dc.identifier.bibliographicCitation | Biomaterials, v.150, pp 100 - 111 | - |
dc.citation.title | Biomaterials | - |
dc.citation.volume | 150 | - |
dc.citation.startPage | 100 | - |
dc.citation.endPage | 111 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | EPITHELIAL-MESENCHYMAL TRANSITION | - |
dc.subject.keywordPlus | SELF-RENEWAL | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ADHESION | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | FATE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | Mechanotransduction of human pluripotent stem cells cultivated on tunable cell-derived extracellular matrix | - |
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