Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetesChanges of myelin basic protein in the hippocampus of an animal model of type 2 diabetes
- Other Titles
- Changes of myelin basic protein in the hippocampus of an animal model of type 2 diabetes
- Authors
- 남성민; 권현정; 김우석; 김종휘; 한규리; 정효영; 김대원; 유대영; 성제경; 황인구; 윤여성
- Issue Date
- 2018
- Publisher
- 한국실험동물학회
- Keywords
- Myelin basic protein; type 2 diabetes; hippocampus; age
- Citation
- Laboratory Animal Research, v.34, no.4, pp 176 - 184
- Pages
- 9
- Journal Title
- Laboratory Animal Research
- Volume
- 34
- Number
- 4
- Start Page
- 176
- End Page
- 184
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6447
- DOI
- 10.5625/lar.2018.34.4.176
- ISSN
- 1738-6055
2233-7660
- Abstract
- In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus of Zucker diabetic fatty (ZDF) rats and their control littermates (Zucker lean control; ZLC). In the ZLC group, body weight steadily increased with age; the body weight of the ZDF group, however, peaked at 30 weeks of age, and subsequently decreased. Based on the changes of body weight, animals were divided into the following six groups: early (12-week), middle (30-week), and chronic (52-week) diabetic groups and their controls. MBP immunoreactivity was found in the alveus, strata pyramidale, and lacunosum-moleculare of the CA1 region, strata pyramidale and radiatum of the CA3 region, and subgranular zone, polymorphic layer, and molecular layer of the dentate gyrus. MBP immunoreactivity was lowest in the hippocampus of 12-week-old rats in the ZLC group, and highest in 12-week-old rats in the ZDF group. Diabetes increased MBP levels in the 12-week-old group, while MBP immunoreactivity decreased in the 30-week-old group. In the 52-week-old ZLC and ZDF groups, MBP immunoreactivity was detected in the hippocampus, similar to the 30-week-old ZDF group. Western blot results corroborated with immunohistochemical results. These results suggested that changes in the immunoreactivity and expression of MBP in the hippocampus might be a compensatory response to aging, while the sustained levels of MBP in diabetic animals could be attributed to a loss of compensatory responses in oligodendrocytes.
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Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
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