Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence
DC Field | Value | Language |
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dc.contributor.author | 김규남 | - |
dc.contributor.author | 유웅선 | - |
dc.contributor.author | 박미화 | - |
dc.contributor.author | 정진권 | - |
dc.contributor.author | 한용섭 | - |
dc.contributor.author | 정인영 | - |
dc.contributor.author | 서성욱 | - |
dc.contributor.author | 유지명 | - |
dc.contributor.author | 김성재 | - |
dc.date.accessioned | 2021-08-11T13:23:35Z | - |
dc.date.available | 2021-08-11T13:23:35Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1011-8942 | - |
dc.identifier.issn | 2092-9382 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6497 | - |
dc.description.abstract | Purpose: To describe the clinical manifestations of herpes simplex keratitis (HSK) in a tertiary referral center in South Korea and to determine whether ascorbic acid treatment prevents recurrence of herpetic epithelial keratitis. Methods: This retrospective cohort study included all consecutive patients with herpetic keratitis referred to our center from January 2010 to January 2015. Clinical features, ocular complications, and recurrences were recorded. Results: In total, 149 eyes of the 133 patients (72 male and 61 female) were followed for an average of 24.6 ± 13.2 months. Sixteen (12.0%) patients had bilateral HSK. The most frequent HSK subtype was epithelial keratitis (49.7%), which was followed by stromal keratitis (23.5%). Epithelial keratitis was the most likely subtype to recur. Complications occurred in 122 (81.9%) eyes. The most common complication was corneal opacity. Recurrences were observed in 48 (32.2%) eyes. The recurrence rates were lower in the prophylactic oral antiviral agent group (16 / 48 eyes, 33.3% vs. 49 / 101 eyes, 48.5%) and the ascorbic acid treatment group (13 / 48 eyes, 27.1% vs. 81 / 101 eyes, 70.3%) compared with the groups without medications. Univariate logistic regression analysis revealed that both factors significantly reduced the risk of recurrence (acyclovir: odds ratio, 0.25; 95% confidence intervals, 0.12 to 0.51; ascorbic acid: odds ratio, 0.51; 95% confidence intervals, 0.20 to 0.91). Conclusions: This retrospective study described the clinical findings of HSK in a tertiary referral center in South Korea. Prophylactic oral antiviral agent treatment and oral ascorbic acid administration may lower the risk of recurrence. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한안과학회 | - |
dc.title | Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence | - |
dc.title.alternative | Clinical Features of Herpes Simplex Keratitis in a Korean Tertiary Referral Center: Efficacy of Oral Antiviral and Ascorbic Acid on Recurrence | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.3341/kjo.2017.0131 | - |
dc.identifier.bibliographicCitation | Korean Journal of Ophthalmology, v.32, no.5, pp 353 - 360 | - |
dc.citation.title | Korean Journal of Ophthalmology | - |
dc.citation.volume | 32 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 353 | - |
dc.citation.endPage | 360 | - |
dc.identifier.kciid | ART002394026 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Acyclovir | - |
dc.subject.keywordAuthor | Ascorbic acid | - |
dc.subject.keywordAuthor | Keratitis | - |
dc.subject.keywordAuthor | herpetic | - |
dc.subject.keywordAuthor | Recurrence | - |
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