발아현미가 LPS로 유도된 지방세포의 염증반응에 미치는 영향
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 박미영 | - |
dc.date.accessioned | 2021-08-11T13:23:46Z | - |
dc.date.available | 2021-08-11T13:23:46Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1225-7060 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6569 | - |
dc.description.abstract | Germinated brown rice (GBR, Orysa sartiva L.) has been reported to have anti-obesity and anti-inflammatory effects. However, the mechanisms underlying these effects in adipocytes are not fully understood. Therefore, this study was conducted to explore the anti-inflammatory mechanisms of GBR on lipopolysaccharide (LPS)-stimulated 3T3-L1 adipocytes. 3T3-L1 adipocytes were pretreated with GBR extracts (0-20 mg/mL) 1 h before LPS stimulation. The mRNA expression of adipokines and Toll-like receptor 4 (TLR4) were measured by RT-PCR. The protein expressions of TLR4- related molecules were detected by western blotting and nuclear factor-κB (NF-κB) activation was measured. Our results showed that GBR extract dose-dependently inhibited mRNA expression of LPS-induced tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). GBR extract was found to inhibit LPS-induced mRNA expression of TLR4 and protein expression of both myeloid differentiation factor 88 (MyD88) and TNF receptorassociated factor 6 (TRAF6). Furthermore, GBR extract significantly inhibited extracellular receptor-activated kinase (ERK) phosphorylation and NF-κB activation. These results suggest that GBR extract has the anti-inflammatory effects on LPSinduced inflammation via inhibition of TLR4 signaling, includingthe ERK and NF-κB signaling pathways, in adipocytes. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 한국식생활문화학회 | - |
dc.title | 발아현미가 LPS로 유도된 지방세포의 염증반응에 미치는 영향 | - |
dc.title.alternative | Effect of Germinated Brown Rice on LPS-Induced Inflammation in Adipocytes | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 박미영 | - |
dc.identifier.doi | 10.7318/KJFC/2018.33.4.337 | - |
dc.identifier.bibliographicCitation | 한국식생활문화학회지, v.33, no.4, pp.337 - 344 | - |
dc.relation.isPartOf | 한국식생활문화학회지 | - |
dc.citation.title | 한국식생활문화학회지 | - |
dc.citation.volume | 33 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 337 | - |
dc.citation.endPage | 344 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002381271 | - |
dc.description.journalClass | 2 | - |
dc.description.journalRegisteredClass | kci | - |
dc.subject.keywordAuthor | Orysa sartiva L. | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Germinated brown rice | - |
dc.subject.keywordAuthor | Toll-like receptor 4 | - |
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