Expression of Jun activation domain-binding protein 1 and p27 Kip1 in endometrial polyps and uterine leiomyomas

Abstract

Aim: The expression, localization, and density of Jab1 and p27 in endometrial polyps and uterine leiomyomas and the associations between these diseases and Jab1 and p27 based on clinical outcomes were explored. Materials and Methods: Tissues from 28 patients (14 with endometrial polyps and 14 with uterine leiomyomas) were used to investigate the expression of Jab1 and p27 by immunohistochemical analysis from November 2011 to April 2014. Results: Jab1 exhibited positive immunoreactivity: 78.5% in the endometrial polyp group in glandular epithelial cells and 71.4% in the uterine leiomyoma group in smooth muscle cells. In contrast to Jab1, p27 exhibited negative immunoreactivity: 76.9% in the endometrial polyp group and 78.6% in the uterine leiomyoma group. The lesions were larger in cases of expressed Jab1 only, rather than in cases with positive or negative expression of both proteins. Tissues that were recurrent did not express p27. Conclusions: Jab1 was expressed in the glandular epithelium of endometrial polyps and stromal layer of uterine leiomyomas, while p27 was suppressed in both diseases. Positive expression of Jab1 and negative expression of p27 were related to lesion growth.