Anti-biofilm and Anti-Virulence Efficacy of Celastrol Against Stenotrophomonas maltophilia
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Hye-Rim | - |
dc.contributor.author | Lee, Dongsup | - |
dc.contributor.author | Eom, Yong-Bin | - |
dc.date.accessioned | 2021-08-11T13:44:05Z | - |
dc.date.available | 2021-08-11T13:44:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1449-1907 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6872 | - |
dc.description.abstract | Stenotrophomonas maltophilia is a multi-drug resistant opportunistic pathogen that causes nosocomial infections in immunocompromised patients. This pathogen is difficult to treat owing to its intrinsic multidrug resistance and ability to form antimicrobial-tolerant biofilms. In the present study, we aimed to assess the potential use of celastrol as a novel anti-biofilm and/or anti-virulence agent against S. maltophilia. Results showed that celastrol at its sub-inhibitory doses decreased biofilm formation and disrupt the established biofilms produced by S. maltophilia. Celastrol-induced decrease in biofilm formation was dose-dependent based on the results of the microtiter plate biofilm assays and confocal laser scanning microscopy. In addition, our data validated the anti-virulence efficacy of celastrol, wherein it significantly interfered with the production of protease and motility of S. maltophilia. To support these phenotypic results, transcriptional analysis revealed that celastrol down-regulated the expression of biofilm- and virulence- associated genes (smeYZ, fsnR, and bfmAK) in S. maltophilia. Interestingly, celastrol significantly inhibited the expression of smeYZ gene, which encodes the resistance-nodulation-division (RND)-type efflux pump, SmeYZ. Overall, our findings suggested that celastrol might be a promising bioactive agent for treatment of biofilm- and virulence-related infections caused by the multi-drug resistant S. maltophilia. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Ivyspring International Publisher | - |
dc.title | Anti-biofilm and Anti-Virulence Efficacy of Celastrol Against Stenotrophomonas maltophilia | - |
dc.type | Article | - |
dc.publisher.location | 호주 | - |
dc.identifier.doi | 10.7150/ijms.23924 | - |
dc.identifier.scopusid | 2-s2.0-85049599041 | - |
dc.identifier.wosid | 000433048200006 | - |
dc.identifier.bibliographicCitation | International Journal of Medical Sciences, v.15, no.6, pp 617 - 627 | - |
dc.citation.title | International Journal of Medical Sciences | - |
dc.citation.volume | 15 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 617 | - |
dc.citation.endPage | 627 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | CYSTIC-FIBROSIS PATIENTS | - |
dc.subject.keywordPlus | STAPHYLOCOCCUS-AUREUS | - |
dc.subject.keywordPlus | DRUG-RESISTANCE | - |
dc.subject.keywordPlus | PATHOGEN | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | BACTERIAL | - |
dc.subject.keywordPlus | GENES | - |
dc.subject.keywordPlus | MICROORGANISMS | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | INFECTIONS | - |
dc.subject.keywordAuthor | Celastrol | - |
dc.subject.keywordAuthor | Stenotrophomonas maltophilia | - |
dc.subject.keywordAuthor | Anti-biofilm | - |
dc.subject.keywordAuthor | Anti-virulence | - |
dc.subject.keywordAuthor | Resistance-nodulation-division (RND)-type efflux pump | - |
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