Association of Ultrafiltration Rate with Mortality in Incident Hemodialysis Patients
DC Field | Value | Language |
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dc.contributor.author | Kim, Tae Woo | - |
dc.contributor.author | Chang, Tae Ik | - |
dc.contributor.author | Kim, Tae Hee | - |
dc.contributor.author | Chou, Jason A. | - |
dc.contributor.author | Soohoo, Melissa | - |
dc.contributor.author | Ravel, Vanessa A. | - |
dc.contributor.author | Kovesdy, Csaba P. | - |
dc.contributor.author | Kalantar-Zadeh, Kamyar | - |
dc.contributor.author | Streja, Elani | - |
dc.date.accessioned | 2021-08-11T13:44:05Z | - |
dc.date.available | 2021-08-11T13:44:05Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1660-8151 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6875 | - |
dc.description.abstract | Background/Aims: Ultrafiltration rate (UFR) appears to be associated with mortality in prevalent hemodialysis (HD) patients. However, the association of UFR with mortality in incident HD patients remains unknown. Methods: We examined a US cohort of 110,880 patients who initiated HD from 2007 to 2011. Baseline UFR was divided into 5 groups (<4, 4 to <6, 6 to <8, 8 to <10, and >= 10 mL/h/kg body weight [BW]). We examined predictors of higher baseline UFR using logistic regression and the association of baseline UFR and all-cause and cardiovascular (CV) mortality using Cox proportional hazard models with adjustments for demographics, comorbidities, and markers of malnutrition-inflammation-cachexia syndrome. Results: Patients were 63 +/- 15 years, with 43% women, 32% African Americans, and had a mean baseline UFR of 7.5 +/- 3.1 mL/h/kg BW. In the fully adjusted logistic regression models, factors associated with higher UFR (>= 7.5 mL/h/kg BW) included Hispanic ethnicity, diabetes, and higher dietary protein intake. There was a linear association between UFR and all-cause and CV mortality, where UFR >= 10 mL/h/kg BW (reference UFR 6-<8 mL/h/kg BW) conferred the highest risk in both unadjusted (HR 1.15 [95% CI 1.10-1.19]) and adjusted models (HR 1.23 [95% CI 1.16-1.31]). The linear association with all-cause mortality remained consistent across strata of age, urine volume, and treatment time. Conclusions: Higher UFR is independently associated with higher all-cause and CV mortality in incident HD patients. Clinical trials are warranted to examine the effects of lowering UFR on outcomes. (C) 2018 S. Karger AG, Basel | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.title | Association of Ultrafiltration Rate with Mortality in Incident Hemodialysis Patients | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000486323 | - |
dc.identifier.wosid | 000431078500002 | - |
dc.identifier.bibliographicCitation | Nephron, v.139, no.1, pp 13 - 22 | - |
dc.citation.title | Nephron | - |
dc.citation.volume | 139 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 13 | - |
dc.citation.endPage | 22 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | INTERDIALYTIC WEIGHT-GAIN | - |
dc.subject.keywordPlus | MAINTENANCE HEMODIALYSIS | - |
dc.subject.keywordPlus | TREATMENT TIME | - |
dc.subject.keywordPlus | ALL-CAUSE | - |
dc.subject.keywordPlus | DIALYSIS | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | NUTRITION | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | HYPOTENSION | - |
dc.subject.keywordPlus | DURATION | - |
dc.subject.keywordAuthor | Ultrafiltration | - |
dc.subject.keywordAuthor | Ultrafiltration rate | - |
dc.subject.keywordAuthor | Mortality | - |
dc.subject.keywordAuthor | Hemodialysis | - |
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