Cancer Stem Cells (CSCs) in Drug Resistance and their Therapeutic Implications in Cancer Treatmentopen access
- Authors
- Lan Thi Hanh Phi; Sari, Ita Novita; Yang, Ying-Gui; Lee, Sang-Hyun; Jun, Nayoung; Kim, Kwang Seock; Lee, Yun Kyung; Kwon, Hyog Young
- Issue Date
- 2018
- Publisher
- Hindawi Publishing Corporation
- Keywords
- cancer stem cells
- Citation
- Stem Cells International, v.2018
- Journal Title
- Stem Cells International
- Volume
- 2018
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6889
- DOI
- 10.1155/2018/5416923
- ISSN
- 1687-966X
1687-9678
- Abstract
- Cancer stem cells (CSCs), also known as tumor-initiating cells (TICs), are suggested to be responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. Thus, it is important to understand the characteristics and mechanisms by which CSCs display resistance to therapeutic agents. In this review, we highlight the key features and mechanisms that regulate CSC function in drug resistance as well as recent breakthroughs of therapeutic approaches for targeting CSCs. This promises new insights of CSCs in drug resistance and provides better therapeutic rationales to accompany novel anticancer therapeutics.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - Graduate School > Department of Integrated Biomedical Science > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.