Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study
DC Field | Value | Language |
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dc.contributor.author | Lee, Sang Hoon | - |
dc.contributor.author | Park, Moo Suk | - |
dc.contributor.author | Kim, Song Yee | - |
dc.contributor.author | Kim, Dong Soon | - |
dc.contributor.author | Kim, Young Whan | - |
dc.contributor.author | Chung, Man Pyo | - |
dc.contributor.author | Uh, Soo Taek | - |
dc.contributor.author | Park, Choon Sik | - |
dc.contributor.author | Park, Sung Woo | - |
dc.contributor.author | Jeong, Sung Hwan | - |
dc.contributor.author | Park, Yong Bum | - |
dc.contributor.author | Lee, Hong Lyeol | - |
dc.contributor.author | Shin, Jong Wook | - |
dc.contributor.author | Lee, Eun Joo | - |
dc.contributor.author | Lee, Jin Hwa | - |
dc.contributor.author | Jegal, Yangin | - |
dc.contributor.author | Lee, Hyun Kyung | - |
dc.contributor.author | Kim, Yong Hyun | - |
dc.contributor.author | Song, Jin Woo | - |
dc.contributor.author | Park, Jong Sun | - |
dc.date.accessioned | 2021-08-11T13:44:10Z | - |
dc.date.available | 2021-08-11T13:44:10Z | - |
dc.date.issued | 2017-12-06 | - |
dc.identifier.issn | 1465-9921 | - |
dc.identifier.issn | 1465-993X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6903 | - |
dc.description.abstract | Background: The effects of corticosteroid-based therapy in patients with idiopathic nonspecific interstitial pneumonia (iNSIP), and factors affecting treatment outcome, are not fully understood. We aimed to investigate the long-term treatment response and factors affecting the treatment outcome in iNSIP patients from a multi-center study in Korea. Methods: The Korean interstitial lung disease (ILD) Study Group surveyed ILD patients from 2003 to 2007. Patients were divided into two groups to compare the treatment response: response group (forced vital capacity (FVC) improves = 10% after 1 year) and non-response group (FVC < 10%). Factors affecting treatment response were evaluated by multivariate logistic regression analysis. Results: A total of 261 patients with iNSIP were enrolled, and 95 patients were followed-up for more than 1 year. Corticosteroid treatment was performed in 86 patients. The treatment group showed a significant improvement in lung function after 1-year: FVC, 10.0%; forced expiratory volume (FEV1), 9.8%; diffusing capacity of the lung for carbon monoxide (DLco), 8.4% (p < 0.001). Sero-negative anti-nuclear antibody (ANA) was significantly related with lung function improvement. Sero-positivity ANA was significantly lower in the response group (p = 0.013), compared to that in the non-response group. A shorter duration of respiratory symptoms at diagnosis was significantly associated with a good response to treatment (p = 0.018). Conclusion: Treatment with corticosteroids and/ or immunosuppressants improved lung function in iNSIP patients, which was more pronounced in sero-negative ANA and shorter symptom duration patients. These findings suggest that early treatment should be considered in iNSIP patients, even in an early disease stage. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Factors affecting treatment outcome in patients with idiopathic nonspecific interstitial pneumonia: a nationwide cohort study | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s12931-017-0686-7 | - |
dc.identifier.scopusid | 2-s2.0-85050662015 | - |
dc.identifier.wosid | 000417509400002 | - |
dc.identifier.bibliographicCitation | Respiratory Research, v.18 | - |
dc.citation.title | Respiratory Research | - |
dc.citation.volume | 18 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | HISTOPATHOLOGIC SUBSETS | - |
dc.subject.keywordPlus | PROGNOSTIC-SIGNIFICANCE | - |
dc.subject.keywordPlus | PULMONARY-FIBROSIS | - |
dc.subject.keywordPlus | LUNG-DISEASE | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Non-specific interstitial pneumonia | - |
dc.subject.keywordAuthor | Treatment | - |
dc.subject.keywordAuthor | Pulmonary lung function | - |
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