Magnolialide의 면역글로블린-E 매개 I형 과민반응에 미치는 억제 효과
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한만덕 | - |
dc.contributor.author | 남궁우 | - |
dc.date.accessioned | 2021-08-11T13:44:15Z | - |
dc.date.available | 2021-08-11T13:44:15Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2017-12 | - |
dc.identifier.issn | 1738-4761 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/6939 | - |
dc.description.abstract | The aim of this study was to investigate the inhibitory effects of magnolialide on basophil-mediated allergic reactions and interleukin (IL)-5-mediated B cell growth. Magnolialide was isolated from the leaves of Laurus nobilis L. (Lauraceae). The effects of magnolialide on mast cell stabilization were determined by measuring immunoglobulin (Ig) E-induced β-hexosaminidase activity in rat basophilic leukemia 2H3 (RBL-2H3) cells. Furthermore, IL-4 production, IL-5-induced Y16 pro-B cell proliferation, and the cytotoxic effects of magnolialide on RBL-2H3 cells were studied. Magnolialide inhibited the release of β-hexosaminidase by RBL-2H3 cells. The IC50 value of magnolialide (21.4 M) was lower than the ketotifen positive control (56.2 M). Additionally, magnolialide was able to inhibit IL-4 mRNA transcription and IL-4 production in IgE-induced RBL-2H3 cells with IC50 values of 17.8 μM and 15.2 μM, respectívely. Magnolíalíde also suppressed pro-B cell growth in IL-5-stimulated Y-16 cells in a dose-dependent manner. These results indicate that magnolialide inhibits IgE-sensitized RBL-2H3 cell de-granulation, IL-4 production, and IL-5 stimulated early during B-cell proliferation. These factors are all key parameters involved in the body’s response to a type 1 hypersensitivity reaction. | - |
dc.language | 한국어 | - |
dc.language.iso | ko | - |
dc.publisher | 순천향대학교 기초과학연구소 | - |
dc.title | Magnolialide의 면역글로블린-E 매개 I형 과민반응에 미치는 억제 효과 | - |
dc.title.alternative | Inhibitory effects of magnolialide on Ig-E-mediated type Ihypersensitivity in vitro | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 한만덕 | - |
dc.contributor.affiliatedAuthor | 남궁우 | - |
dc.identifier.bibliographicCitation | 순천향 자연과학연구 논문집, v.23, no.2, pp.171 - 177 | - |
dc.relation.isPartOf | 순천향 자연과학연구 논문집 | - |
dc.citation.title | 순천향 자연과학연구 논문집 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 171 | - |
dc.citation.endPage | 177 | - |
dc.type.rims | ART | - |
dc.description.journalClass | 3 | - |
dc.subject.keywordAuthor | Magnolialide | - |
dc.subject.keywordAuthor | Ig-E | - |
dc.subject.keywordAuthor | I형 과민반응 | - |
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