The Effect of Biocomposite Screws on Bone Regeneration in a Rat Osteoporosis Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Je Hoon | - |
dc.contributor.author | Jin, Eun-Sun | - |
dc.contributor.author | Kim, Ji Yeon | - |
dc.contributor.author | Lee, Bora | - |
dc.contributor.author | Min, JoongKee | - |
dc.contributor.author | Jeon, Sang Ryong | - |
dc.contributor.author | Lee, Minsu | - |
dc.contributor.author | Choi, Kyoung Hyo | - |
dc.date.accessioned | 2021-08-11T14:24:13Z | - |
dc.date.available | 2021-08-11T14:24:13Z | - |
dc.date.issued | 2017-10 | - |
dc.identifier.issn | 1878-8750 | - |
dc.identifier.issn | 1878-8769 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7146 | - |
dc.description.abstract | OBJECTIVE: To evaluate the efficacy of biocomposite screws used in ovariectomy (OVX)-induced osteoporotic rats. METHODS: Twenty-four female Wistar rats (250-300 g, 12 weeks old) were divided into 4 groups: sham group (control), OVX-induced osteoporosis group (OVX), OVX and biodegradable poly(lactic-co-glycolic acid) (PLGA) without tricalcium phosphate (beta-TCP) screw insertion group (OVX/BSR), and OVX and biocomposite (PLGA with b-TCP) screw insertion group (OVX/CSR). Three groups underwent bilateral OVX, and of these, 2 groups had 2 different types of screw inserted at the proximal tibia. At 25 weeks after OVX, the bilateral tibias were extracted. The extracted tibiae were scanned by ex vivo micro-computed tomography (CT) and stained with hematoxylin and eosin (H&E) and with Masson's trichrome stain for pathological assessment. RESULTS: Compared with the ovariectomized groups, the control group had the highest values for bone mineral density (BMD), bone volume (BV)/total volume (TV), and trabecular number (Tb.N) and the lowest values for trabecular thickness (Tb.Th) and trabecular separation (Tb.Sp). In the pairwise comparison among ovariectomized groups, the OVX/CSR group had significantly higher BMD, BV/TV, and Tb.N values than the other 2 groups (OVX and OVX/BSR) and significantly lower Tb.Sp. Micro-CT scans showed clear evidence of new trabecular formation near the screw insertion site in the OVX/CSR group only. Analyses of H&E- and Masson's trichrome-stained sections showed more and thicker trabecular bone around the implant in the OVX/CSR group compared with the OVX and OVX/BSR groups. CONCLUSIONS: Biocomposite screws can improve local bone quality and facilitate osteoconductivity in an osteoporotic rat model. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | The Effect of Biocomposite Screws on Bone Regeneration in a Rat Osteoporosis Model | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/J.WNEU.2017.07.083 | - |
dc.identifier.scopusid | 2-s2.0-85030324525 | - |
dc.identifier.wosid | 000415850400122 | - |
dc.identifier.bibliographicCitation | World Neurosurgery, v.106, pp 964 - 972 | - |
dc.citation.title | World Neurosurgery | - |
dc.citation.volume | 106 | - |
dc.citation.startPage | 964 | - |
dc.citation.endPage | 972 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Surgery | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Surgery | - |
dc.subject.keywordPlus | CRUCIATE LIGAMENT RECONSTRUCTION | - |
dc.subject.keywordPlus | L-LACTIC ACID | - |
dc.subject.keywordPlus | INTERFERENCE SCREWS | - |
dc.subject.keywordPlus | GRAFT FIXATION | - |
dc.subject.keywordPlus | RESORBABLE CERAMICS | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | COMPOSITE | - |
dc.subject.keywordPlus | STRENGTH | - |
dc.subject.keywordPlus | TITANIUM | - |
dc.subject.keywordAuthor | Animal model | - |
dc.subject.keywordAuthor | Biodegradable screw | - |
dc.subject.keywordAuthor | Bone morphogenetic protein 2 | - |
dc.subject.keywordAuthor | Osteoporosis | - |
dc.subject.keywordAuthor | Screw | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.