Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Hyemin | - |
dc.contributor.author | Bae, Eun-Kyung | - |
dc.contributor.author | Kim, Hunnyun | - |
dc.contributor.author | Eun, Yeong Hee | - |
dc.contributor.author | Kim, In Young | - |
dc.contributor.author | Kim, Hyungjin | - |
dc.contributor.author | Lee, Jaejoon | - |
dc.contributor.author | Jeon, Chan Hong | - |
dc.contributor.author | Koh, Eun-Mi | - |
dc.contributor.author | Cha, Hoon-Suk | - |
dc.date.accessioned | 2021-08-11T14:24:27Z | - |
dc.date.available | 2021-08-11T14:24:27Z | - |
dc.date.issued | 2017-09-07 | - |
dc.identifier.issn | 1478-6354 | - |
dc.identifier.issn | 1478-6362 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7217 | - |
dc.description.abstract | Background: Ankylosing spondylitis (AS) is a male-predominant disease, and radiographic evidence of damage is also more severe in males. Estrogen modulates immune-related processes such as T cell differentiation and cytokine production. This study aimed to evaluate the effect of estrogen on the disease activity of spondyloarthritis (SpA). Methods: The effects of estrogen on the development of arthritis were evaluated by performing ovariectomy and 17 beta-estradiol (E2) pellet implantation in zymosan-treated SKG mice. Clinical arthritis scores were measured, and F-18-fluorodeoxyglucose (F-18-FDG) small-animal positron emission tomography/computed tomography performed to quantify joint inflammation. The expression of inflammatory cytokines in joint tissue was measured. Results: E2-treated mice showed remarkable suppression of arthritis clinically and little infiltration of inflammatory cells in the Achilles tendon and intervertebral disc. F-18-FDG uptake was significantly lower in E2-treated mice than in sham-operated (sham) and ovariectomized mice. Expression of TNF, interferon-gamma, and IL-17A was significantly reduced in E2-treated mice, whereas expression of sclerostin and Dickkopf-1 was increased in E2-treated mice compared with sham and ovariectomized mice. Conclusions: Estrogen suppressed arthritis development in SKG mice, a model of SpA. Results of this study suggest that estrogen has an anti-inflammatory effect on the spondyloarthritis manifestations of the SKG arthritis model. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | BioMed Central | - |
dc.title | Estrogen attenuates the spondyloarthritis manifestations of the SKG arthritis model | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1186/s13075-017-1407-9 | - |
dc.identifier.scopusid | 2-s2.0-85028925415 | - |
dc.identifier.wosid | 000409496900001 | - |
dc.identifier.bibliographicCitation | Arthritis Research & Therapy, v.19 | - |
dc.citation.title | Arthritis Research & Therapy | - |
dc.citation.volume | 19 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Rheumatology | - |
dc.relation.journalWebOfScienceCategory | Rheumatology | - |
dc.subject.keywordPlus | NONRADIOGRAPHIC AXIAL SPONDYLOARTHRITIS | - |
dc.subject.keywordPlus | ACTIVE ANKYLOSING-SPONDYLITIS | - |
dc.subject.keywordPlus | BONE MASS | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | SCLEROSTIN | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | DICKKOPF-1 | - |
dc.subject.keywordPlus | PROTECTION | - |
dc.subject.keywordAuthor | Estrogen | - |
dc.subject.keywordAuthor | Spondyloarthritis | - |
dc.subject.keywordAuthor | Mice | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.