A Mathematical Model for the Macrophage Response to Respiratory Viral Infection in Normal and Asthmatic Conditions
DC Field | Value | Language |
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dc.contributor.author | Lee, Junehyuk | - |
dc.contributor.author | Adler, Frederick R. | - |
dc.contributor.author | Kim, Peter S. | - |
dc.date.accessioned | 2021-08-11T14:24:33Z | - |
dc.date.available | 2021-08-11T14:24:33Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0092-8240 | - |
dc.identifier.issn | 1522-9602 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7258 | - |
dc.description.abstract | Respiratory viral infections are common in the general population and one of the most important causes of asthma aggravation and exacerbation. Despite many studies, it is not well understood how viral infections cause more severe symptoms and exacerbations in asthmatics. We develop a mathematical model of two types of macrophages that play complementary roles in fighting viral infection: classically (CA-M Phi) and alternatively activated macrophages (AA-M Phi). CA-M Phi destroy infected cells and tissues to remove viruses, while AA-M Phi repair damaged tissues. We show that a higher viral load or longer duration of infection provokes a stronger immune response from the macrophage system. By adjusting the parameters, we model the differences in response to respiratory viral infection in normal and asthmatic subjects and show how this skews the system toward a response that generates more severe symptoms in asthmatic patients. | - |
dc.format.extent | 20 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academic Press | - |
dc.title | A Mathematical Model for the Macrophage Response to Respiratory Viral Infection in Normal and Asthmatic Conditions | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s11538-017-0315-0 | - |
dc.identifier.scopusid | 2-s2.0-85025687425 | - |
dc.identifier.wosid | 000410478100002 | - |
dc.identifier.bibliographicCitation | Bulletin of Mathematical Biology, v.79, no.9, pp 1979 - 1998 | - |
dc.citation.title | Bulletin of Mathematical Biology | - |
dc.citation.volume | 79 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1979 | - |
dc.citation.endPage | 1998 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Mathematical & Computational Biology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Mathematical & Computational Biology | - |
dc.subject.keywordPlus | NITRIC-OXIDE SYNTHASE | - |
dc.subject.keywordPlus | BRONCHIAL EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | ACUTE EXACERBATIONS | - |
dc.subject.keywordPlus | PCR ASSAY | - |
dc.subject.keywordPlus | T-CELLS | - |
dc.subject.keywordPlus | VIRUS | - |
dc.subject.keywordPlus | BETA | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CYTOKINES | - |
dc.subject.keywordAuthor | Macrophage | - |
dc.subject.keywordAuthor | Respiratory tract virus | - |
dc.subject.keywordAuthor | Asthma | - |
dc.subject.keywordAuthor | Exacerbation | - |
dc.subject.keywordAuthor | Mathematical immunology | - |
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