Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, Woo Seok | - |
dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Yang, Sungjae | - |
dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Yoo, Byong Chul | - |
dc.contributor.author | Cho, Jae Youl | - |
dc.date.accessioned | 2021-08-11T14:24:39Z | - |
dc.date.available | 2021-08-11T14:24:39Z | - |
dc.date.issued | 2017-09 | - |
dc.identifier.issn | 0939-4451 | - |
dc.identifier.issn | 1438-2199 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7290 | - |
dc.description.abstract | Among the enzymes involved in the post-translational modification of Ras, isoprenyl carboxyl methyltransferase (ICMT) has been explored by a number of researchers as a significant enzyme controlling the activation of Ras. Indeed, inhibition of ICMT exhibited promising anti-cancer activity against various cancer cell lines. This paper reviews patents and research articles published between 2009 and 2016 that reported inhibitors of ICMT as potential chemotherapeutic agents targeting Ras-induced growth factor signaling. Since ICMT inhibitors can modulate Ras signaling pathway, it might be possible to develop a new class of anti-cancer drugs targeting Ras-related cancers. Researchers have discovered indole-based small-molecular ICMT inhibitors through high-throughput screening. Researchers at Duke University identified a prototypical inhibitor, cysmethynil. At Singapore University, Ramanujulu and his colleagues patented more potent compounds by optimizing cysmethynil. In addition, Rodriguez and Stevenson at Universidad Complutense De Madrid and Cancer Therapeutics CRC PTY Ltd., respectively, have developed inhibitors based on formulas other than the indole base. However, further optimization of chemicals targeted to functional groups is needed to improve the characteristics of ICMT inhibitors related to their application as drugs, such as solubility, effectiveness, and safety, to facilitate clinical use. | - |
dc.format.extent | 17 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Isoprenyl carboxyl methyltransferase inhibitors: a brief review including recent patents | - |
dc.type | Article | - |
dc.publisher.location | 오스트리아 | - |
dc.identifier.doi | 10.1007/s00726-017-2454-x | - |
dc.identifier.scopusid | 2-s2.0-85021057546 | - |
dc.identifier.wosid | 000407922900003 | - |
dc.identifier.bibliographicCitation | Amino Acids, v.49, no.9, pp 1469 - 1485 | - |
dc.citation.title | Amino Acids | - |
dc.citation.volume | 49 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1469 | - |
dc.citation.endPage | 1485 | - |
dc.type.docType | Review | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.subject.keywordPlus | FARNESYL TRANSFERASE INHIBITORS | - |
dc.subject.keywordPlus | SMALL-MOLECULE INHIBITOR | - |
dc.subject.keywordPlus | CANCER-CELLS | - |
dc.subject.keywordPlus | K-RAS | - |
dc.subject.keywordPlus | FARNESYLTRANSFERASE INHIBITORS | - |
dc.subject.keywordPlus | SACCHAROMYCES-CEREVISIAE | - |
dc.subject.keywordPlus | ICMT INHIBITORS | - |
dc.subject.keywordPlus | ANALOGS | - |
dc.subject.keywordPlus | CARBOXYLMETHYLTRANSFERASE | - |
dc.subject.keywordPlus | INACTIVATION | - |
dc.subject.keywordAuthor | ICMT inhibitor | - |
dc.subject.keywordAuthor | Cancer | - |
dc.subject.keywordAuthor | Methylation | - |
dc.subject.keywordAuthor | Cysmethynil | - |
dc.subject.keywordAuthor | Ras | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.