Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area
DC Field | Value | Language |
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dc.contributor.author | Park, Joon Ha | - |
dc.contributor.author | Lee, Tae-Kyeong | - |
dc.contributor.author | Yan, Bing-Chun | - |
dc.contributor.author | Shin, Bich-Na | - |
dc.contributor.author | Ahn, Ji Hyeon | - |
dc.contributor.author | Kim, In Hye | - |
dc.contributor.author | Cho, Jeong Hwi | - |
dc.contributor.author | Lee, Jae-Chul | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Kim, Jong Dai | - |
dc.contributor.author | Hong, Seongkweon | - |
dc.contributor.author | Lee, Young Joo | - |
dc.contributor.author | Won, Moo-Ho | - |
dc.contributor.author | Kang, Il Jun | - |
dc.date.accessioned | 2021-08-11T14:43:41Z | - |
dc.date.available | 2021-08-11T14:43:41Z | - |
dc.date.issued | 2017-08-05 | - |
dc.identifier.issn | 0366-6999 | - |
dc.identifier.issn | 2542-5641 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7303 | - |
dc.description.abstract | Background: Glehnia littoralis, as a traditional herbal medicine to heal various health ailments in East Asia, displays various therapeutic properties including antioxidant effects. However, neuroprotective effects of G. littoralis against cerebral ischemic insults have not yet been addressed. Therefore, in this study, we first examined its neuroprotective effects in the hippocampus using a gerbil model of transient global cerebral ischemia (TGCI). Methods: Gerbils were subjected to TGCI for 5 min. G. littoralis extract (GLE; 100 and 200 mg/kg) was administrated orally once daily for 7 days before ischemic surgery. Neuroprotection was examined by neuronal nuclear antigen immunohistochemistry and Fluoro-Jade B histofluorescence staining. Gliosis was observed by immunohistochemistry for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1. For neuroprotective mechanisms, immunohistochemistry for superoxide dismutase (SOD) 1 and brain-derived neurotrophic factor (BDNF) was done. Results: Pretreatment with 200 mg/kg of GLE protected pyramidal neurons in the cornu ammonis 1 (CA1) area from ischemic insult area (F = 29.770, P < 0.05) and significantly inhibited activations of astrocytes (F = 22.959, P < 0.05) and microglia (F = 44.135, P < 0.05) in the ischemic CA1 area. In addition, pretreatment with GLE significantly increased expressions of SOD1 (F = 28.561, P < 0.05) and BDNF (F = 55.298, P < 0.05) in CA1 pyramidal neurons of the sham- and ischemia-operated groups. Conclusions: Our findings indicate that pretreatment with GLE can protect neurons from ischemic insults, and we suggest that its neuroprotective mechanism may be closely associated with increases of SOD1 and BDNF expressions as well as attenuation of glial activation. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Zhonghua Yixeuehui Zazhishe/Chinese Medical Association Publishing House | - |
dc.title | Pretreated Glehnia littoralis Extract Prevents Neuronal Death Following Transient Global Cerebral Ischemia through Increases of Superoxide Dismutase 1 and Brain-derived Neurotrophic Factor Expressions in the Gerbil Hippocampal Cornu Ammonis 1 Area | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.4103/0366-6999.211554 | - |
dc.identifier.wosid | 000407134800007 | - |
dc.identifier.bibliographicCitation | Chinese Medical Journal, v.130, no.15, pp 1796 - 1803 | - |
dc.citation.title | Chinese Medical Journal | - |
dc.citation.volume | 130 | - |
dc.citation.number | 15 | - |
dc.citation.startPage | 1796 | - |
dc.citation.endPage | 1803 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PYRAMIDAL NEURONS | - |
dc.subject.keywordPlus | GLIAL ACTIVATION | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CA1 REGION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | INJURY | - |
dc.subject.keywordPlus | NEUROPROTECTION | - |
dc.subject.keywordPlus | PROTECTS | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | SUPPRESSION | - |
dc.subject.keywordAuthor | Antioxidant | - |
dc.subject.keywordAuthor | Glial Activation | - |
dc.subject.keywordAuthor | Neurotrophic Factor | - |
dc.subject.keywordAuthor | Neuroprotection | - |
dc.subject.keywordAuthor | Pyramidal Neurons | - |
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