The serum pepsinogen levels for risk assessment of gastric neoplasms New proposal from a case-control study in Korea
DC Field | Value | Language |
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dc.contributor.author | Cho, Jun-Hyung | - |
dc.contributor.author | Jeon, Seong Ran | - |
dc.contributor.author | Kim, Hyun Gun | - |
dc.contributor.author | Jin, So-Young | - |
dc.contributor.author | Park, Suyeon | - |
dc.date.accessioned | 2021-08-11T14:43:58Z | - |
dc.date.available | 2021-08-11T14:43:58Z | - |
dc.date.issued | 2017-07 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7397 | - |
dc.description.abstract | To decrease the gastric cancer related mortality rate, endoscopic screening is widely performed in Korea. However, a precise method for identifying those at a high risk of gastric neoplasms has not been established. This study aims to evaluate serum pepsinogen (PG) levels for risk assessment of gastric neoplasms. Between August 2014 and March 2016, a total of 398 subjects, including 87 with gastric neoplasms, were enrolled in this study. On the basis of the serum PG I/II ratio, the enrolled subjects were classified into 4 groups: group A, PG I/II ratio > 4; group B, > 3 and <= 4; group C, > 2 and <= 3; group D, <= 2. Compared with group A, a stepwise increase in the risk of gastric neoplasm was observed from group B [ odds ratio (OR) = 9.9, 95% confidence interval (95% CI) = 4.0-24.4] to group C (OR = 20.9, 95% CI = 8.7-50.5) to group D (OR = 37.3, 95% CI = 14.3-97.4). The optimal cutoff value of the serum PG I/II ratio for predicting gastric neoplasms was 4.5, with a sensitivity of 97.7% and a specificity of 57.6%. A decrease in the serum PG I/II ratio was strongly associated with an increased risk of gastric neoplasms. The serum PG I/II ratio can be used to identify those at a high risk of gastric neoplasms in Korean population. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | The serum pepsinogen levels for risk assessment of gastric neoplasms New proposal from a case-control study in Korea | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MD.0000000000007603 | - |
dc.identifier.scopusid | 2-s2.0-85026416221 | - |
dc.identifier.wosid | 000406477600071 | - |
dc.identifier.bibliographicCitation | Medicine, v.96, no.29 | - |
dc.citation.title | Medicine | - |
dc.citation.volume | 96 | - |
dc.citation.number | 29 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | HELICOBACTER-PYLORI INFECTION | - |
dc.subject.keywordPlus | CANCER SCREENING-PROGRAM | - |
dc.subject.keywordPlus | ATROPHIC GASTRITIS | - |
dc.subject.keywordPlus | ANTIBODY | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | MUCOSA | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | ENDOSCOPY | - |
dc.subject.keywordAuthor | atrophy | - |
dc.subject.keywordAuthor | gastric neoplasm | - |
dc.subject.keywordAuthor | Helicobacter pylori | - |
dc.subject.keywordAuthor | pepsinogen | - |
dc.subject.keywordAuthor | risk | - |
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