Relationship among age, insulin resistance, and blood pressure
- Authors
- Jung, Chan-Hee; Jung, Sang Hee; Lee, Bora; Rosenberg, Melanie; Reaven, Gerald M.; Kim, Sun H.
- Issue Date
- Jun-2017
- Publisher
- Elsevier BV
- Keywords
- Hypertension; insulin suppression test; prehypertension; steady-state plasma glucose
- Citation
- Journal of the American Society of Hypertension, v.11, no.6, pp 359 - 365
- Pages
- 7
- Journal Title
- Journal of the American Society of Hypertension
- Volume
- 11
- Number
- 6
- Start Page
- 359
- End Page
- 365
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7512
- DOI
- 10.1016/j.jash.2017.04.005
- ISSN
- 1933-1711
1878-7436
- Abstract
- The effect of age to modify the relationship between insulin resistance and hypertension is unclear. In this retrospective, cross-sectional study, median age was used to create two age groups (<52 vs. >= 52 years), and comparisons were made of metabolic characteristics, including steady-state plasma glucose (SSPG) concentrations measured during the insulin suppression test to quantify insulin resistance. Individuals were stratified into SSPG tertiles and categorized as having normal blood pressure (BP), prehypertension, or hypertension. SSPG concentrations were similar in the two age groups (161 vs. 164 mg/dL). In the most insulin-resistant tertile, distribution of normal BP, prehypertension, and hypertension was equal in those aged <52 years, whereas in those aged >= 52 years, prevalence of hypertension was increased approximately fivefold compared with those with normal BP. Multivariate regression analysis demonstrated significant interaction between age and SSPG in predicting systolic BP (P = .023). In stratified analysis, SSPG, but not age, was an independent predictor of systolic BP and diastolic BP in >= 52 years group, whereas the reverse was true in the younger group. The adverse impact of insulin resistance on BP was accentuated in older individuals and may have a greater impact than further aging. Copyright (C) 2017 American Society of Hypertension. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Internal Medicine > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.