Supplementation with Triptolide Increases Resistance to Environmental Stressors and Lifespan in C-elegans
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Sung-Jin | - |
dc.contributor.author | Beak, Sun-Mi | - |
dc.contributor.author | Park, Sang-Kyu | - |
dc.date.accessioned | 2021-08-11T14:44:20Z | - |
dc.date.available | 2021-08-11T14:44:20Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0022-1147 | - |
dc.identifier.issn | 1750-3841 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7517 | - |
dc.description.abstract | Triptolide is a major active compound found in Tripterygium wilfordii., also known as Thunder God Vine. Triptolide has been shown to have anti-inflammatory and anticancer activities. In this study, we examined the effect of dietary supplementation with triptolide on response to environmental stressors and lifespan in vivo using Caenorhabditis elegans as a model system. Treatment with 50 mg/L of triptolide in the growth media increased resistance to oxidative stress and reduced the generation of intracellular reactive oxygen species. We also observed a lifespan-extending activity for triptolide. Both mean and maximum lifespans were significantly increased by supplementation with triptolide. Response to other environmental stressors was modulated by triptolide. The survival after heat shock or UV irradiation was markedly increased in worms treated with triptolide. Unlike many lifespan-extending genetic or nutritional interventions, the longevity phenotype conferred by triptolide did not have the trade-off of a reduction in fertility or a delay in the gravid period. The expressions of hsp-16.2 and sod-3, known to positively correlate with a long lifespan, were significantly upregulated by supplementation with triptolide. These findings suggest that triptolide can exhibit antistress and lifespan-extending effects in vivo, possibly through its antioxidant activity and support the free radical theory of aging, which emphasizes the causative role of oxidative stress in aging. Practical Application This study revealed that triptolide has a beneficial effect on both stress response and lifespan in C. elegans. With validating evidence in higher organisms, triptolide can be used for the development of anti-aging nutritional supplements or therapeutics. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Institute of Food Technologists | - |
dc.title | Supplementation with Triptolide Increases Resistance to Environmental Stressors and Lifespan in C-elegans | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/1750-3841.13720 | - |
dc.identifier.scopusid | 2-s2.0-85018457723 | - |
dc.identifier.wosid | 000403012800024 | - |
dc.identifier.bibliographicCitation | Journal of Food Science, v.82, no.6, pp 1484 - 1490 | - |
dc.citation.title | Journal of Food Science | - |
dc.citation.volume | 82 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 1484 | - |
dc.citation.endPage | 1490 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | CONTAINING SUPEROXIDE-DISMUTASE | - |
dc.subject.keywordPlus | OXIDATIVE STRESS | - |
dc.subject.keywordPlus | CALORIC RESTRICTION | - |
dc.subject.keywordPlus | DIETARY RESTRICTION | - |
dc.subject.keywordPlus | TRANSGENIC MICE | - |
dc.subject.keywordPlus | OVEREXPRESSION | - |
dc.subject.keywordPlus | EXTENSION | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.subject.keywordPlus | LONGEVITY | - |
dc.subject.keywordPlus | CATALASE | - |
dc.subject.keywordAuthor | C | - |
dc.subject.keywordAuthor | elegans | - |
dc.subject.keywordAuthor | lifespan | - |
dc.subject.keywordAuthor | reactive oxygen species | - |
dc.subject.keywordAuthor | stress response | - |
dc.subject.keywordAuthor | triptolide | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.