Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease A Korean nationwide, multicenter, retrospective, observational, cohort study
DC Field | Value | Language |
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dc.contributor.author | Park, Jung Gil | - |
dc.contributor.author | Tak, Won Young | - |
dc.contributor.author | Park, Soo Young | - |
dc.contributor.author | Kweon, Young Oh | - |
dc.contributor.author | Jang, Se Young | - |
dc.contributor.author | Lee, Yu Rim | - |
dc.contributor.author | Bae, Si Hyun | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Kim, Do Young | - |
dc.contributor.author | Lee, June Sung | - |
dc.contributor.author | Suk, Ki Tae | - |
dc.contributor.author | Kim, In Hee | - |
dc.contributor.author | Lee, Heon Ju | - |
dc.contributor.author | Chung, Woo Jin | - |
dc.contributor.author | Jang, Byoung Kuk | - |
dc.contributor.author | Suh, Jeong Ill | - |
dc.contributor.author | Heo, Jeong | - |
dc.contributor.author | Lee, Won Kee | - |
dc.date.accessioned | 2021-08-11T14:44:21Z | - |
dc.date.available | 2021-08-11T14:44:21Z | - |
dc.date.issued | 2017-06 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7525 | - |
dc.description.abstract | Evidence of the potential benefits of long-term oral branched-chain amino acid (BCAA) supplementation in reducing the severity of liver disease is limited. Patients who were diagnosed with liver cirrhosis with a Child-Pugh (CP) score of 8-10 were included. The BCAA group consumed BCAAs daily for at least 6 months, and the control group consumed a diet without BCAA. We analyzed the improvements based on the model for end-stage liver disease (MELD) score, CP score, incidence of cirrhosis-related complications, and event-free survival over 2 years. Among the 867 recruited patients, 307 (166 in the BCAA group and 141 in the control group) were analyzed. The BCAA group was divided into 3 subgroups, whose patients consumed 4.15g, 8.3g, or 12.45g of BCAAs daily for the analysis. There were significant differences in the CP score, albumin, and hepatic encephalopathy between the 2 groups at baseline. After matching the propensity scores, we analyzed patients in the BCAA-12.45g group (12.45g of BCAAs daily, n=41) and matched control group (n=41). The MELD score significantly improved in the BCCA-12.45g group compared to the matched control group (P=.004). The changes in the serum bilirubin level (P=.014) and CP score (P=.033) over time also differed significantly between the 2 groups. The incidence rates of cirrhosis-related complications (P=.973) and development of hepatocellular carcinoma (2 cases each) did not differ significantly between the 2 groups. Long-term oral BCAA supplementation has beneficial effects in patients with advanced liver cirrhosis. A further large-scale prospective study is needed to delineate these beneficial effects. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Effects of branched-chain amino acids (BCAAs) on the progression of advanced liver disease A Korean nationwide, multicenter, retrospective, observational, cohort study | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MD.0000000000006580 | - |
dc.identifier.scopusid | 2-s2.0-85022020751 | - |
dc.identifier.wosid | 000403594100001 | - |
dc.identifier.bibliographicCitation | Medicine, v.96, no.24 | - |
dc.citation.title | Medicine | - |
dc.citation.volume | 96 | - |
dc.citation.number | 24 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PROPENSITY SCORE METHODS | - |
dc.subject.keywordPlus | EVENT-FREE SURVIVAL | - |
dc.subject.keywordPlus | PROTEIN-SYNTHESIS | - |
dc.subject.keywordPlus | HEPATIC-ENCEPHALOPATHY | - |
dc.subject.keywordPlus | ORAL SUPPLEMENTATION | - |
dc.subject.keywordPlus | NUTRITIONAL SUPPORT | - |
dc.subject.keywordPlus | ESPEN GUIDELINES | - |
dc.subject.keywordPlus | CIRRHOSIS | - |
dc.subject.keywordPlus | GRANULES | - |
dc.subject.keywordPlus | LEUCINE | - |
dc.subject.keywordAuthor | branched-chain amino acid | - |
dc.subject.keywordAuthor | complication | - |
dc.subject.keywordAuthor | liver cirrhosis | - |
dc.subject.keywordAuthor | nutrition | - |
dc.subject.keywordAuthor | prognosis | - |
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