Enhancement of brain plasticity and recovery of locomotive function after lumbar spinal cord stimulation in combination with gait training with partial weight support in rats with cerebral ischemia
DC Field | Value | Language |
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dc.contributor.author | Choi, Yoon-Hee | - |
dc.contributor.author | Lee, Shi-Uk | - |
dc.date.accessioned | 2021-08-11T14:44:29Z | - |
dc.date.available | 2021-08-11T14:44:29Z | - |
dc.date.issued | 2017-05-01 | - |
dc.identifier.issn | 0006-8993 | - |
dc.identifier.issn | 1872-6240 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7563 | - |
dc.description.abstract | Lumbar spinal cord stimulation (LSCS) is reportedly effective for the recovery of locomotive intraspinal neural network, motor cortex and basal ganglia in animals with complete spinal cord injury and parkinsonism. We evaluated the effect of LSCS in combination with gait training on the recovery of locomotive function and brain plasticity using a rat model of brain ischemia. Adult male Sprague Dawley rats with ischemia were randomly assigned into one of four groups: sham treatment (group 1), LSCS only (group 2), LSCS with gait training and 50% (group 3) and 80% (group 4) of body weight support. Evaluations before randomization and 4 weeks after intervention included motor scoring index, real-time PCR and Western blot. Motor scoring index was significantly improved after the intervention in groups 2 and 3. The ratio of phospho-protein kinase C (PKC) to PKC measured in the infarcted area tended to be higher in groups 3 and 4. Protein expression of mGluR2 and mRNA expression of mGluR1 measured in the contralateral cortex were lower in groups 3 and 4. The ratio of phospho-Akt to Akt and mRNA expression of vascular endothelial growth factor measured in the ischemic border zone were higher in group 2. The mRNA expression of MAP1b measured in the infarcted area was significantly higher in group 2. The findings suggest that LSCS and gait training with an adequate amount of body weight support may promote brain plasticity and facilitate the functional recovery. (C) 2017 Elsevier B.V. All rights reserved. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Enhancement of brain plasticity and recovery of locomotive function after lumbar spinal cord stimulation in combination with gait training with partial weight support in rats with cerebral ischemia | - |
dc.type | Article | - |
dc.publisher.location | 네델란드 | - |
dc.identifier.doi | 10.1016/j.brainres.2017.02.017 | - |
dc.identifier.scopusid | 2-s2.0-85014382370 | - |
dc.identifier.wosid | 000400717000005 | - |
dc.identifier.bibliographicCitation | Brain Research, v.1662, pp 31 - 38 | - |
dc.citation.title | Brain Research | - |
dc.citation.volume | 1662 | - |
dc.citation.startPage | 31 | - |
dc.citation.endPage | 38 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | PRIMARY CORTICAL-NEURONS | - |
dc.subject.keywordPlus | CENTRAL-NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | GROWTH-FACTOR VEGF | - |
dc.subject.keywordPlus | TREADMILL LOCOMOTION | - |
dc.subject.keywordPlus | PARKINSONS-DISEASE | - |
dc.subject.keywordPlus | PATTERN GENERATORS | - |
dc.subject.keywordPlus | ARTERY OCCLUSION | - |
dc.subject.keywordPlus | CHRONIC PAIN | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Spinal cord stimulation | - |
dc.subject.keywordAuthor | Rehabilitation | - |
dc.subject.keywordAuthor | Recovery | - |
dc.subject.keywordAuthor | Plasticity | - |
dc.subject.keywordAuthor | Brain ischemia | - |
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