Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures
- Authors
- Yu, Yeon Hee; Lee, Kahyun; Sin, Dal Sik; Park, Kyung-Ho; Park, Dae-Kyoon; Kim, Duk-Soo
- Issue Date
- May-2017
- Publisher
- Elsevier BV
- Keywords
- Febrile seizure; GABA(A)-alpha 1; Calretinin; Field excitatory postsynaptic potential; Epileptogenesis; Paired-pulse response
- Citation
- Brain Research Bulletin, v.131, pp 25 - 38
- Pages
- 14
- Journal Title
- Brain Research Bulletin
- Volume
- 131
- Start Page
- 25
- End Page
- 38
- URI
- https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7588
- DOI
- 10.1016/j.brainresbull.2017.02.009
- ISSN
- 0361-9230
1873-2747
- Abstract
- Febrile seizure (FS) is the most common seizure type in infants and young children. FS may induce functional changes in the hippocampal circuitries. Abnormality of excitatory and inhibitory neurotrans-missions was previously related to wide-spread seizure attack in the hippocampus following recurrent seizure onset. To clarify the involvement of expressional changes and functional alterations of hippocampal interneurons with epileptogenesis following FS, we investigated long-term effects following recurrent seizure in a hyperthermia-induced seizure animal model. At 12 weeks following FS, the recurrent seizure time period, local field potentials (LFP) revealed high amplitude potential and a sharp wave characteristic of epilepsy. Mossy fiber reorganization in the hippocampus was also detected as abnormal synaptic connection at 8 weeks. Calretinin (CR) - positive interneurons were transiently enhanced during epileptogenic period at 7-9 weeks after FS in the CA1 and DG region and it is double labeled with VGLUT-1. However, although GABA(A)-alpha 1 immunoreactivities were un-changed as similar to control hippocampus at 7-9 weeks after seizure onset, its expression was significantly enhanced at 4 weeks and 12 weeks and it is colocalized with GABA. Furthermore, the field excitatory postsynaptic potential (fEPSP) and the paired-pulse responses including population spike (PS) latency, excitability ratio and PS2/PS1 ratio were markedly altered in the CA1 and DG region at 12 weeks after FS. Therefore, our findings in present study indicate that these time-dependent changes may be based on the persistent alterations of hippocampal neuronal circuits in balance between excitatory and inhibitory responses, and may lead to the epileptogenesis and spread of seizure activity following FS. (C) 2017 Elsevier Inc. All rights reserved.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Medicine > Department of Anatomy > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7588)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.