Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma
DC Field | Value | Language |
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dc.contributor.author | Park, Sang Joon | - |
dc.contributor.author | Jang, Jae Young | - |
dc.contributor.author | Jeong, Soung Won | - |
dc.contributor.author | Cho, Young Kyu | - |
dc.contributor.author | Lee, Sae Hwan | - |
dc.contributor.author | Kim, Sang Gyune | - |
dc.contributor.author | Cha, Sang-Woo | - |
dc.contributor.author | Kim, Young Seok | - |
dc.contributor.author | Cho, Young Deok | - |
dc.contributor.author | Kim, Hong Soo | - |
dc.contributor.author | Kim, Boo Sung | - |
dc.contributor.author | Park, Suyeon | - |
dc.contributor.author | Bang, Hae In | - |
dc.date.accessioned | 2021-08-11T15:24:14Z | - |
dc.date.available | 2021-08-11T15:24:14Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0025-7974 | - |
dc.identifier.issn | 1536-5964 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7736 | - |
dc.description.abstract | Alpha-fetoprotein (AFP), Lens culinaris-agglutinin-reactive fraction of AFP (AFP-L3), and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). This study compared the diagnostic values of AFP, AFP-L3, and PIVKA-II individually and in combination to find the best biomarker or biomarker panel. Seventy-nine patients with newly diagnosed HCC and 77 non-HCC control patients with liver cirrhosis were enrolled. AFP, AFP-L3, and PIVKA-II were measured in the same serum samples using microchip capillary electrophoresis and a liquid-phase binding assay on an automatic analyzer. Receiver-operating characteristic curve analyses were also applied to all combinations of the markers. When the 3 biomarkers were analyzed individually, AFP showed the largest area under the receiver-operating characteristic curve (AUC) (0.751). For combinations of the biomarkers, the AUC was highest (0.765) for '' PIVKA- II> 40mAU/mL and AFP> 10ng/ mL.'' The combination of '' PIVKA- II> 40mAU/ mL and AFP> 10ng/ mL and AFP-L3> 10%" had worse sensitivity and lower AUC ( P= 0.001). The highest AUC of a single biomarker was highest for AFP and of a combination was '' PIVKA- II> 40mAU/ mL and AFP> 10 ng/ mL," with this also being the case when the cut-off value of AFP and AFP-L3 was changed. Alpha-fetoprotein showed the best diagnostic performance as a single biomarker for HCC. The diagnostic value of AFP was improved by combining it with PIVKA-II, but adding AFP-L3 did not contribute to the ability to distinguish between HCC and non-HCC liver cirrhosis. These findings were not altered when the cut-off value of AFP and AFP-L3 was changed. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Usefulness of AFP, AFP-L3, and PIVKA-II, and their combinations in diagnosing hepatocellular carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/MD.0000000000005811 | - |
dc.identifier.scopusid | 2-s2.0-85016009478 | - |
dc.identifier.wosid | 000397613800001 | - |
dc.identifier.bibliographicCitation | Medicine, v.96, no.11 | - |
dc.citation.title | Medicine | - |
dc.citation.volume | 96 | - |
dc.citation.number | 11 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | GAMMA-CARBOXY PROTHROMBIN | - |
dc.subject.keywordPlus | REACTIVE ALPHA-FETOPROTEIN | - |
dc.subject.keywordPlus | FOLLOW-UP | - |
dc.subject.keywordPlus | CIRRHOTIC-PATIENTS | - |
dc.subject.keywordPlus | CLINICAL UTILITY | - |
dc.subject.keywordPlus | CARBOXYPROTHROMBIN | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | HEPATITIS | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | MARKERS | - |
dc.subject.keywordAuthor | AFP | - |
dc.subject.keywordAuthor | AFP-L3 | - |
dc.subject.keywordAuthor | diagnostic value | - |
dc.subject.keywordAuthor | hepatocellular carcinoma | - |
dc.subject.keywordAuthor | PIVKA-II | - |
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