Association of grade of non-alcoholic fatty liver disease and glycated albumin to glycated hemoglobin ratio in patients with type 2 diabetes mellitus
DC Field | Value | Language |
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dc.contributor.author | Jung, Chan-Hee | - |
dc.contributor.author | Lee, Bora | - |
dc.contributor.author | Choi, Dug-Hyun | - |
dc.contributor.author | Jung, Sang-Hee | - |
dc.contributor.author | Kim, Bo-Yeon | - |
dc.contributor.author | Kim, Chul-Hee | - |
dc.contributor.author | Kang, Sung-Koo | - |
dc.contributor.author | Mok, Ji-Oh | - |
dc.date.accessioned | 2021-08-11T15:24:15Z | - |
dc.date.available | 2021-08-11T15:24:15Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0168-8227 | - |
dc.identifier.issn | 1872-8227 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7740 | - |
dc.description.abstract | Aims: The aim of this study was to investigate the association between the glycated albumin (GA) to glycated hemoglobin (HbA1c) (GA/HbA1c) ratio and grade of non-alcoholic fatty liver disease (NAFLD) on ultrasonography (US) in patients with type 2 diabetes mellitus (T2DM). Methods: This retrospective, cross-sectional study was performed with data obtained from 186 T2DM patients. Participants were assessed for serum GA/HbA1c ratio and fatty liver using US. NAFLD was defined as ultrasonographically detected fatty liver and was graded as normal, mild, moderate, and severe fatty liver. Results: A total of 98 subjects (53%) were diagnosed with NAFLD on US, of which 47 (48%) had moderate-to-severe grade of NAFLD. The mean GA level and GA/HbA1c ratio significantly decreased across increasing NAFLD stages (34% vs. 29% vs. 27% vs. 28%, p = 0.023 for trend; 3.1 vs. 2.9 vs. 2.6 vs. 2.7, p = 0.001 for trend, respectively), whereas there was no significant difference in HbA1c level among groups (p = 0.714 for trend). There was a significant decrease in prevalence of NAFLD across GA/HbA1c ratio tertiles (67% vs. 58% vs. 41%, p for trend = 0.007). Multivariate logistic regression analysis showed that individuals with the lowest GA/HbA1c ratio had an odds ratio (OR) of 2.75 (95% CI = 1.06-7.13) for having any grade of NAFLD and an OR of 4.48 [1.20-16.74] for moderate-to-severe grade NAFLD compared with the highest GA/HbA1c ratio even after adjustment for confounding factors (p = 0.038, p = 0.026, respectively). Conclusion: The present study showed that GA/HbA1c ratio was significantly inversely associated with the presence and severity of NAFLD on US. (C) 2016 Elsevier Ireland Ltd. All rights reserved. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Association of grade of non-alcoholic fatty liver disease and glycated albumin to glycated hemoglobin ratio in patients with type 2 diabetes mellitus | - |
dc.type | Article | - |
dc.publisher.location | 아일랜드 | - |
dc.identifier.doi | 10.1016/j.diabres.2016.12.017 | - |
dc.identifier.scopusid | 2-s2.0-85012278914 | - |
dc.identifier.wosid | 000397907000007 | - |
dc.identifier.bibliographicCitation | Diabetes Research and Clinical Practice, v.125, pp 53 - 61 | - |
dc.citation.title | Diabetes Research and Clinical Practice | - |
dc.citation.volume | 125 | - |
dc.citation.startPage | 53 | - |
dc.citation.endPage | 61 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | INSULIN-RESISTANCE | - |
dc.subject.keywordPlus | PREVALENCE | - |
dc.subject.keywordPlus | STEATOHEPATITIS | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | MANAGEMENT | - |
dc.subject.keywordPlus | INCREASES | - |
dc.subject.keywordPlus | FIBROSIS | - |
dc.subject.keywordPlus | SPECTRUM | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Non-alcoholic fatty liver disease | - |
dc.subject.keywordAuthor | Glycated albumin to glycated | - |
dc.subject.keywordAuthor | hemoglobin ratio | - |
dc.subject.keywordAuthor | Glycated albumin | - |
dc.subject.keywordAuthor | Glycated hemoglobin | - |
dc.subject.keywordAuthor | Type 2 diabetes mellitus | - |
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