Efficacy and safety of aprepitant for the prevention of chemotherapy-induced nausea and vomiting during the first cycle of moderately emetogenic chemotherapy in Korean patients with a broad range of tumor types
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong Eun | - |
dc.contributor.author | Jang, Joung-Soon | - |
dc.contributor.author | Kim, Jae-Weon | - |
dc.contributor.author | Sung, Yong Lee | - |
dc.contributor.author | Cho, Chi-Heum | - |
dc.contributor.author | Lee, Myung-Ah | - |
dc.contributor.author | Kim, Do-Jin | - |
dc.contributor.author | Ahn, Myung-Ju | - |
dc.contributor.author | Lee, Kil Yeon | - |
dc.contributor.author | Sym, Sun Jin | - |
dc.contributor.author | Lim, Myong Choel | - |
dc.contributor.author | Jung, Hun | - |
dc.contributor.author | Cho, Eun Kim | - |
dc.contributor.author | Min, Kyung Wan | - |
dc.date.accessioned | 2021-08-11T15:24:17Z | - |
dc.date.available | 2021-08-11T15:24:17Z | - |
dc.date.issued | 2017-03 | - |
dc.identifier.issn | 0941-4355 | - |
dc.identifier.issn | 1433-7339 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7751 | - |
dc.description.abstract | This study evaluated the efficacy and safety of a 3-day aprepitant regimen for the prevention of chemotherapy-induced nausea and vomiting (CINV) during the first cycle of non-anthracycline plus cyclophosphamide (AC)-based moderately emetogenic chemotherapy (MEC) based on government guidelines in Korean patients. This multicenter, randomized, double-blind, phase IV trial (NCT01636947) enrolled adult South Korean patients with a broad range of tumor types who were scheduled to receive a single dose of ae1 MEC agent. Patients were randomized to a 3-day regimen of aprepitant (aprepitant regimen) or placebo (control regimen) on top of ondansetron plus dexamethasone. The primary and key secondary efficacy endpoints were the proportions of subjects who achieved no vomiting and complete response (CR) during the overall phase. Of the 494 randomized subjects, 480 were included in the modified intent-to-treat population. Response rates for no vomiting and CR in the overall phase were numerically higher for the aprepitant regimen compared with the control regimen groups, but failed to reach statistical significance (no vomiting 77.2 vs 72.0%; p = 0.191; CR 73.4 vs 70.4%; p = 0.458). Both the aprepitant and control regimens were generally well tolerated. A 3-day aprepitant regimen was numerically better but not statistically superior to a control regimen with respect to the achievement of no vomiting or CR during the overall phase in a non-AC MEC Korean population based on government reimbursement guidelines. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Springer Verlag | - |
dc.title | Efficacy and safety of aprepitant for the prevention of chemotherapy-induced nausea and vomiting during the first cycle of moderately emetogenic chemotherapy in Korean patients with a broad range of tumor types | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1007/s00520-016-3463-0 | - |
dc.identifier.scopusid | 2-s2.0-84994389340 | - |
dc.identifier.wosid | 000393740400012 | - |
dc.identifier.bibliographicCitation | Supportive Care in Cancer, v.25, no.3, pp 801 - 809 | - |
dc.citation.title | Supportive Care in Cancer | - |
dc.citation.volume | 25 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 801 | - |
dc.citation.endPage | 809 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Health Care Sciences & Services | - |
dc.relation.journalResearchArea | Rehabilitation | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Health Care Sciences & Services | - |
dc.relation.journalWebOfScienceCategory | Rehabilitation | - |
dc.subject.keywordPlus | PLACEBO-CONTROLLED TRIAL | - |
dc.subject.keywordPlus | HIGH-DOSE CISPLATIN | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | NEUROKININ-1 ANTAGONIST | - |
dc.subject.keywordPlus | GUIDELINE UPDATE | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | ANTIEMETICS | - |
dc.subject.keywordPlus | PERCEPTION | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordPlus | CINV | - |
dc.subject.keywordAuthor | Aprepitant | - |
dc.subject.keywordAuthor | Neurokinin-1 receptor antagonists | - |
dc.subject.keywordAuthor | Moderately emetogenic chemotherapy | - |
dc.subject.keywordAuthor | Chemotherapy-induced nausea and vomiting | - |
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