Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells
DC Field | Value | Language |
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dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Yoo, Byong Chul | - |
dc.contributor.author | Myung, Jae Kyung | - |
dc.date.accessioned | 2021-08-11T15:24:26Z | - |
dc.date.available | 2021-08-11T15:24:26Z | - |
dc.date.issued | 2017-02-02 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7789 | - |
dc.description.abstract | Calgranulin B is known to be involved in tumor development, but the underlying molecular mechanism is not clear. To gain insight into possible roles of calgranulin B, we screened for calgranulin B-interacting molecules in the SNU-484 gastric cancer and the SNU-81 colon cancer cells. Calgranulin B-interacting partners were identified by yeast two-hybrid and functional information was obtained by computational analysis. Most of the calgranulin B interacting partners were involved in metabolic and cellular processes, and found to have molecular function of binding and catalytic activities. Interestingly, 46 molecules in the network of the calgranulin B-interacting proteins are known to be associated with cancer and FKBP2 was found to interact with calgranulin B in both SNU-484 and SNU-81 cells. Polyubiquitin-C encoded by UBC, which exhibited an interaction with calgranulin B, has been associated with various molecules of the extracellular space and plasma membrane identified in our screening, including Na-K-CI cotransporter 1 and dystonin in SNU-484 cells, and ATPase subunit beta-1 in SNU-81 cells. Our data provide novel insight into the roles of calgranulin B of gastrointestinal cancer cells, and offer new clues suggesting calgranulin B acts as an effector molecule through which the cell can communicate with the tumor microenvironment via polyubiquitin-C. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Public Library of Science | - |
dc.title | Identification of calgranulin B interacting proteins and network analysis in gastrointestinal cancer cells | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1371/journal.pone.0171232 | - |
dc.identifier.scopusid | 2-s2.0-85011635977 | - |
dc.identifier.wosid | 000396161200112 | - |
dc.identifier.bibliographicCitation | PLoS ONE, v.12, no.2 | - |
dc.citation.title | PLoS ONE | - |
dc.citation.volume | 12 | - |
dc.citation.number | 2 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RAPAMYCIN-BINDING-PROTEIN | - |
dc.subject.keywordPlus | QUANTITATIVE PROTEOMICS | - |
dc.subject.keywordPlus | PLASMA-MEMBRANE | - |
dc.subject.keywordPlus | NA+/K+-ATPASE | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | S100A8/A9 | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | MRP-14 | - |
dc.subject.keywordAuthor | calgranulin B | - |
dc.subject.keywordAuthor | gastrointestinal cancer cells | - |
dc.subject.keywordAuthor | proteins | - |
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