Effect of Single and Double Administration of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Focal Cerebral Ischemia in Rats
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Hyung Woo | - |
dc.contributor.author | Kim, Yona | - |
dc.contributor.author | Chang, Jong Wook | - |
dc.contributor.author | Yang, Yoon Sun | - |
dc.contributor.author | Oh, Wonil | - |
dc.contributor.author | Lee, Jae Min | - |
dc.contributor.author | Park, Hye Ran | - |
dc.contributor.author | Kim, Dong Gyu | - |
dc.contributor.author | Paek, Sun Ha | - |
dc.date.accessioned | 2021-08-11T15:24:34Z | - |
dc.date.available | 2021-08-11T15:24:34Z | - |
dc.date.issued | 2017-02 | - |
dc.identifier.issn | 1226-2560 | - |
dc.identifier.issn | 2093-8144 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7828 | - |
dc.description.abstract | Stem cell therapies are administered during the acute phase of stroke to preserve the penumbral tissues from ischemic injury. However, the effect of repeated cell therapy during the acute phase remains unclear. In this study, we investigated and compared the functional outcome of single (two days post-injury) and repeated (two and nine days post-injury) treatment with human umbilical cord derived mesenchymal stem cells (hUCB-MSCs) after middle cerebral artery occlusion (MCAO). The rotarod and limb placement tests were utilized to investigate functional outcomes, while infarct volume and tissue damage were measured by immunofluorescent staining for neovascularization, neurogenesis, apoptosis, and inflammation in the penumbral zones. We observed notable motor dysfunction and a significant decrease in infarcted brain volume, as well as increases in neurons and vessels in both single and repeated hUCB-MSC treatments compared to the control group. Interestingly, repeated administration of hUCB-MSCs was not found to elicit additional or synergistic improvements over monotherapy. This study suggests that a clearer understanding of the therapeutic window after stroke will facilitate the development of more efficient treatment protocols in the clinical application of stem cell therapy. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 한국뇌신경과학회 | - |
dc.title | Effect of Single and Double Administration of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Following Focal Cerebral Ischemia in Rats | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.5607/en.2017.26.1.55 | - |
dc.identifier.scopusid | 2-s2.0-85013784626 | - |
dc.identifier.wosid | 000406862000006 | - |
dc.identifier.bibliographicCitation | Experimental Neurobiology, v.26, no.1, pp 55 - 65 | - |
dc.citation.title | Experimental Neurobiology | - |
dc.citation.volume | 26 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 55 | - |
dc.citation.endPage | 65 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002202517 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | MARROW STROMAL CELLS | - |
dc.subject.keywordPlus | BONE-MARROW | - |
dc.subject.keywordPlus | ADULT-RAT | - |
dc.subject.keywordPlus | THERAPEUTIC BENEFIT | - |
dc.subject.keywordPlus | FUNCTIONAL RECOVERY | - |
dc.subject.keywordPlus | GROWTH-FACTOR | - |
dc.subject.keywordPlus | BRAIN-INJURY | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordPlus | TRANSPLANTATION | - |
dc.subject.keywordAuthor | Human umbilical cord blood mesenchymal stem cell | - |
dc.subject.keywordAuthor | Ischemia | - |
dc.subject.keywordAuthor | repeat therapy | - |
dc.subject.keywordAuthor | Angiogenesis | - |
dc.subject.keywordAuthor | Neurogenesis | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.