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Prognostic value of bone marrow F-18-FDG uptake on PET/CT in lymphoma patients with negative bone marrow involvement

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dc.contributor.authorLee, Jeong Won-
dc.contributor.authorLee, Sang-Cheol-
dc.contributor.authorKim, Han Jo-
dc.contributor.authorLee, Sang Mi-
dc.date.accessioned2021-08-11T15:43:45Z-
dc.date.available2021-08-11T15:43:45Z-
dc.date.issued2017-01-
dc.identifier.issn1790-5427-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7907-
dc.description.abstractOBJECTIVE:The study evaluated the significance of F-18 fluorodeoxyglucose (F-18-FDG) uptake of bone marrow (BM) for predicting progression-free survival (PFS) in lymphoma patients without BM involvement. SUBJECTS AND METHODS:Ninety-five patients with histopathologically proven lymphoma, 7 Hodgkin's lymphoma and 88 non-Hodgkin's lymphoma, who underwent F-18-FDG positron emission tomography/computed tomography (PET/CT) and BM biopsy for staging work-up and 40 normal subjects were retrospectively enrolled. Maximal F-18-FDG uptake of lymphoma (Lmax), mean F-18-FDG uptake of BM (BM SUV) and BM-to-liver uptake ratio (BLR) were measured. Prognostic value of BM SUV and BLR for predicting PFS were assessed. RESULTS:Of the 95 patients, 35 (36.8%) were histopathologically or clinically diagnosed with BM involvement of lymphoma. There were significant differences of BLR among lymphoma patients with/without BM involvement and normal subjects (P<0.05). For all patients, high risk indicated by International Prognostic Index (IPI) score and Lmax were significantly associated with PFS on multivariate analysis (P<0.05). For 60 patients without BM involvement, BM SUV and BLR were independent prognostic factors for PFS along with performance status and Lmax (p<0.05). Among patients without BM involvement, high F-18-FDG uptake of BM was associated with significantly worse PFS than low F-18-FDG uptake of BM, with no significant difference in PFS apparent compared to patients with BM involvement. CONCLUSION:In lymphoma patients without BM involvement, F-18-FDG uptake of BM was significantly associated with worse PFS. Patients with high F-18-FDG uptake of BM showed similar prognosis to those with BM involvement.-
dc.format.extent9-
dc.language영어-
dc.language.isoENG-
dc.publisherHellenic Society of Nuclear Medicine-
dc.titlePrognostic value of bone marrow F-18-FDG uptake on PET/CT in lymphoma patients with negative bone marrow involvement-
dc.typeArticle-
dc.publisher.location그리이스-
dc.identifier.scopusid2-s2.0-85021853475-
dc.identifier.wosid000401079500004-
dc.identifier.bibliographicCitationHellenic Journal of Nuclear Medicine, v.20, no.1, pp 17 - 25-
dc.citation.titleHellenic Journal of Nuclear Medicine-
dc.citation.volume20-
dc.citation.number1-
dc.citation.startPage17-
dc.citation.endPage25-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaRadiology, Nuclear Medicine & Medical Imaging-
dc.relation.journalWebOfScienceCategoryRadiology, Nuclear Medicine & Medical Imaging-
dc.subject.keywordPlusB-CELL LYMPHOMA-
dc.subject.keywordPlusNON-HODGKINS-LYMPHOMA-
dc.subject.keywordPlusRESPONSE ASSESSMENT-
dc.subject.keywordPlusFDG-PET/CT-
dc.subject.keywordPlusDIAGNOSIS-
dc.subject.keywordPlusCRITERIA-
dc.subject.keywordPlusBIOPSY-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusRATIO-
dc.subject.keywordAuthorLymphoma-
dc.subject.keywordAuthorF-18-FDG PET-
dc.subject.keywordAuthorBone marrow-
dc.subject.keywordAuthorPrognosis-
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