Prognostic value of bone marrow F-18-FDG uptake on PET/CT in lymphoma patients with negative bone marrow involvement
DC Field | Value | Language |
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dc.contributor.author | Lee, Jeong Won | - |
dc.contributor.author | Lee, Sang-Cheol | - |
dc.contributor.author | Kim, Han Jo | - |
dc.contributor.author | Lee, Sang Mi | - |
dc.date.accessioned | 2021-08-11T15:43:45Z | - |
dc.date.available | 2021-08-11T15:43:45Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1790-5427 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7907 | - |
dc.description.abstract | OBJECTIVE:The study evaluated the significance of F-18 fluorodeoxyglucose (F-18-FDG) uptake of bone marrow (BM) for predicting progression-free survival (PFS) in lymphoma patients without BM involvement. SUBJECTS AND METHODS:Ninety-five patients with histopathologically proven lymphoma, 7 Hodgkin's lymphoma and 88 non-Hodgkin's lymphoma, who underwent F-18-FDG positron emission tomography/computed tomography (PET/CT) and BM biopsy for staging work-up and 40 normal subjects were retrospectively enrolled. Maximal F-18-FDG uptake of lymphoma (Lmax), mean F-18-FDG uptake of BM (BM SUV) and BM-to-liver uptake ratio (BLR) were measured. Prognostic value of BM SUV and BLR for predicting PFS were assessed. RESULTS:Of the 95 patients, 35 (36.8%) were histopathologically or clinically diagnosed with BM involvement of lymphoma. There were significant differences of BLR among lymphoma patients with/without BM involvement and normal subjects (P<0.05). For all patients, high risk indicated by International Prognostic Index (IPI) score and Lmax were significantly associated with PFS on multivariate analysis (P<0.05). For 60 patients without BM involvement, BM SUV and BLR were independent prognostic factors for PFS along with performance status and Lmax (p<0.05). Among patients without BM involvement, high F-18-FDG uptake of BM was associated with significantly worse PFS than low F-18-FDG uptake of BM, with no significant difference in PFS apparent compared to patients with BM involvement. CONCLUSION:In lymphoma patients without BM involvement, F-18-FDG uptake of BM was significantly associated with worse PFS. Patients with high F-18-FDG uptake of BM showed similar prognosis to those with BM involvement. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Hellenic Society of Nuclear Medicine | - |
dc.title | Prognostic value of bone marrow F-18-FDG uptake on PET/CT in lymphoma patients with negative bone marrow involvement | - |
dc.type | Article | - |
dc.publisher.location | 그리이스 | - |
dc.identifier.scopusid | 2-s2.0-85021853475 | - |
dc.identifier.wosid | 000401079500004 | - |
dc.identifier.bibliographicCitation | Hellenic Journal of Nuclear Medicine, v.20, no.1, pp 17 - 25 | - |
dc.citation.title | Hellenic Journal of Nuclear Medicine | - |
dc.citation.volume | 20 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 17 | - |
dc.citation.endPage | 25 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | B-CELL LYMPHOMA | - |
dc.subject.keywordPlus | NON-HODGKINS-LYMPHOMA | - |
dc.subject.keywordPlus | RESPONSE ASSESSMENT | - |
dc.subject.keywordPlus | FDG-PET/CT | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | BIOPSY | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | RATIO | - |
dc.subject.keywordAuthor | Lymphoma | - |
dc.subject.keywordAuthor | F-18-FDG PET | - |
dc.subject.keywordAuthor | Bone marrow | - |
dc.subject.keywordAuthor | Prognosis | - |
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