Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma
DC Field | Value | Language |
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dc.contributor.author | Jung, Hae Il | - |
dc.contributor.author | Jeong, Dongjun | - |
dc.contributor.author | Ji, Sanghee | - |
dc.contributor.author | Ahn, Tae Sung | - |
dc.contributor.author | Bae, Sang Ho | - |
dc.contributor.author | Chin, Susie | - |
dc.contributor.author | Chung, Jun Chul | - |
dc.contributor.author | Kim, Hyung Chul | - |
dc.contributor.author | Lee, Moon Soo | - |
dc.contributor.author | Baek, Moo-Jun | - |
dc.date.accessioned | 2021-08-11T15:43:50Z | - |
dc.date.available | 2021-08-11T15:43:50Z | - |
dc.date.issued | 2017-01 | - |
dc.identifier.issn | 1598-2998 | - |
dc.identifier.issn | 2005-9256 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/7928 | - |
dc.description.abstract | Purpose Hepatocellular carcinoma (HCC) is one of the most aggressive malignancies. Recently, the overexpression of programmed cell death 1. (PD-1) and PD-1 ligand 1 (PD-L1) has been shown to correlate with poor prognosis in many cancers. However, the expression of PD-L1 or PD-1 ligand 2 (PD-L2) and clinical outcomes have not been fully investigated in HCC. Materials and Methods Formalin-fixed paraffin-embedded samples were obtained from 85 patients with HCC who underwent surgery. The expression of PD-Ls (PD-L1, PD-L2) was evaluated by immunohistochemical analysis. Results The proportion of high expression groups of PD-L1 and PD-L2 was 27.1% and 23.5%, respectively. Univariate analysis revealed that tumor size (p < 0.001), histological differentiation (p=0.010), PD-L1 expression (p < 0.001), and PD-L2 expression (p=0.039) were significant prognostic factors of overall survival in patients with HCC. Multivariate analysis revealed that overall tumor size (hazard ratio [HR], 4.131; 95% confidence interval [CI], 2.233 to 7.643; p < 0.001 and HR, 3.455; 95% CI, 1.967 to 6.067; p < 0.001) and PD-L1 expression (HR, 5.172; 95% CI, 2.661 to 10.054; p < 0.001 and HR, 3.730; 95% CI, 1.453 to 9.574; p=0.006) were independent prognostic values for overall and disease-free survival. Patients with high expression of PD-Ls had a significantly poorer survival than those with low expression (p < 0.001, p=0.034). Conclusion The overexpression of PD-Ls in HCC patients is correlated with survival and tumor recurrence. Further evaluation of PD-1 and PD-Ls as therapeutic targets and predictive biomarkers for HCC is warranted. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한암학회 | - |
dc.title | Overexpression of PD-L1 and PD-L2 Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4143/crt.2016.066 | - |
dc.identifier.scopusid | 2-s2.0-85010369350 | - |
dc.identifier.wosid | 000391899800026 | - |
dc.identifier.bibliographicCitation | Cancer Research and Treatment, v.49, no.1, pp 246 - 254 | - |
dc.citation.title | Cancer Research and Treatment | - |
dc.citation.volume | 49 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 246 | - |
dc.citation.endPage | 254 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002190217 | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.subject.keywordPlus | CANCER-IMMUNOTHERAPY | - |
dc.subject.keywordPlus | BLOCKADE | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | HEPATITIS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordAuthor | Hepatocellular carcinoma | - |
dc.subject.keywordAuthor | Programmed cell death 1 | - |
dc.subject.keywordAuthor | Programmed cell death 1 ligand | - |
dc.subject.keywordAuthor | Prognosis | - |
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