A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 오윤택 | - |
dc.contributor.author | 이나경 | - |
dc.date.accessioned | 2021-08-11T15:44:21Z | - |
dc.date.available | 2021-08-11T15:44:21Z | - |
dc.date.created | 2021-06-17 | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8128 | - |
dc.description.abstract | Bone-resorbing osteoclasts play a major role in maintaining bone homeostasis with bone-forming osteoblasts. Although it has been reported that A2B adenosine receptor (A2BAR) regulates osteoclast differentiation, its effects on apoptosis or proliferation of osteoclasts have been less-defined. Here, we demonstrate that A2BAR stimulation regulates macrophage-colony stimulating factor (M-CSF)-mediated osteoclast proliferation. Stimulation with a specific agonist of A2BAR, BAY 60-6583, significantly reduced M-CSF-mediated osteoclast proliferation in a time- and dose-dependent manner. In addition, A2BAR stimulation induced both apoptosis of the cells and cell arrest in the G1 phase with a decrease of cell number in the G2/M phase. Stimulation with BAY 60-6583 inhibited the activation of Akt by M-CSF, whereas M-CSF-induced ERK1/2 activation was not affected. These results suggest that the inhibition of M-CSF-mediated Akt activation by A2BAR stimulation increases apoptotic response of osteoclasts and induces cell cycle arrest in the G1 phase, thus contributing to the down-regulation of osteoclast proliferation. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 대한의생명과학회 | - |
dc.title | A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation | - |
dc.title.alternative | A2B Adenosine Receptor Stimulation Down-regulates M-CSF-mediated Osteoclast Proliferation | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | 이나경 | - |
dc.identifier.doi | 10.15616/BSL.2017.23.3.194 | - |
dc.identifier.bibliographicCitation | 대한의생명과학회지, v.23, no.3, pp.194 - 200 | - |
dc.relation.isPartOf | 대한의생명과학회지 | - |
dc.citation.title | 대한의생명과학회지 | - |
dc.citation.volume | 23 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 194 | - |
dc.citation.endPage | 200 | - |
dc.type.rims | ART | - |
dc.identifier.kciid | ART002270861 | - |
dc.description.journalClass | 3 | - |
dc.subject.keywordAuthor | M-CSF | - |
dc.subject.keywordAuthor | Osteoclast proliferation | - |
dc.subject.keywordAuthor | A2B adenosine receptor | - |
dc.subject.keywordAuthor | Akt | - |
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