Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signaling pathway in diet-induced obesity mouse model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Baek, Hye Kyung | - |
dc.contributor.author | Kim, Pan Soo | - |
dc.contributor.author | Song, Ji Ae | - |
dc.contributor.author | Choi, Dong-Hwa | - |
dc.contributor.author | Kim, Do Eun | - |
dc.contributor.author | Il Oh, Seung | - |
dc.contributor.author | Park, Sang-Kyu | - |
dc.contributor.author | Kim, Sung-Jo | - |
dc.contributor.author | Song, Ki-Duk | - |
dc.contributor.author | Hwang, In Koo | - |
dc.contributor.author | Seo, Hyung Seok | - |
dc.contributor.author | Yi, Sun Shin | - |
dc.date.accessioned | 2021-08-11T16:24:17Z | - |
dc.date.available | 2021-08-11T16:24:17Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1229-845X | - |
dc.identifier.issn | 1976-555X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8384 | - |
dc.description.abstract | Recently, we reported that Artemisia annua (AA) has anti-adipogenic properties in vitro and in vivo. Reduction of adipogenesis by AA treatment may dampen systemic inflammation and protect neurons from cytokine-induced damage. Therefore, the present study was undertaken to assess whether AA increases neuronal maturation by reducing inflammatory responses, such as those mediated by cyclooxygenase 2 (COX-2). Mice were fed normal chow or a high-fat diet with or without chronic daily oral administration of AA extract (0.2 g/10 mL/kg) for 4 weeks; then, changes in their hippocampal dentate gyri were measured via immunohistochemistry/immunofluorescence staining for bromodexoxyuridine, doublecortin, and neuronal nuclei, markers of neuronal maturation, and quantitative western blotting for COX-2 and Iba-1, in order to assess correlations between systemic inflammation (interleukin-6) and food type. Additionally, we tested the effect of AA in an Alzheimer's disease model of Caenorhabditis elegans and uncovered a potential benefit. The results show that chronic AA dosing significantly increases neuronal maturation, particularly in the high-fat diet group. This effect was seen in the absence of any changes in COX-2 levels in mice given the same type of food, pointing to the possibility of alternate anti-inflammatory pathways in the stimulation of neurogenesis and neuro-maturation in a background of obesity. | - |
dc.format.extent | 9 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | 대한수의학회 | - |
dc.title | Neuronal maturation in the hippocampal dentate gyrus via chronic oral administration of Artemisa annua extract is independent of cyclooxygenase 2 signaling pathway in diet-induced obesity mouse model | - |
dc.type | Article | - |
dc.publisher.location | 대한민국 | - |
dc.identifier.doi | 10.4142/jvs.2017.18.2.119 | - |
dc.identifier.scopusid | 2-s2.0-85021112893 | - |
dc.identifier.wosid | 000403920800001 | - |
dc.identifier.bibliographicCitation | Journal of Veterinary Science, v.18, no.2, pp 119 - 127 | - |
dc.citation.title | Journal of Veterinary Science | - |
dc.citation.volume | 18 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 119 | - |
dc.citation.endPage | 127 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002233197 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Veterinary Sciences | - |
dc.relation.journalWebOfScienceCategory | Veterinary Sciences | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | TREADMILL EXERCISE | - |
dc.subject.keywordPlus | ADIPOSE-TISSUE | - |
dc.subject.keywordPlus | IMMUNOREACTIVITY | - |
dc.subject.keywordPlus | INTERLEUKIN-6 | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | BRAIN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | RATS | - |
dc.subject.keywordAuthor | Artemisia annua | - |
dc.subject.keywordAuthor | anti-obesity | - |
dc.subject.keywordAuthor | cyclooxygenase 2 | - |
dc.subject.keywordAuthor | neurogenesis | - |
dc.subject.keywordAuthor | neuro-maturation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.