Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease
DC Field | Value | Language |
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dc.contributor.author | Kim, Sei Won | - |
dc.contributor.author | Rhee, Chin Kook | - |
dc.contributor.author | Kim, Ki Uk | - |
dc.contributor.author | Lee, Sang Haak | - |
dc.contributor.author | Hwang, Hun Gyu | - |
dc.contributor.author | Kim, Yu Il | - |
dc.contributor.author | Kim, Deog Kyeom | - |
dc.contributor.author | Do Lee, Sang | - |
dc.contributor.author | Oh, Yeon-Mok | - |
dc.contributor.author | Yoon, Hyoung Kyu | - |
dc.date.accessioned | 2021-08-11T16:24:18Z | - |
dc.date.available | 2021-08-11T16:24:18Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1176-9106 | - |
dc.identifier.issn | 1178-2005 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8391 | - |
dc.description.abstract | Background: Interleukin (IL)-33 promotes T helper (Th)2 immunity and systemic inflammation. The role of IL-33 in asthma has been widely investigated. IL-33 has also been suggested to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study investigated the clinical significance and usefulness of plasma IL-33 level in patients with COPD. Methods: A total of 307 patients with stable COPD from 15 centers, who were in the Korean Obstructive Lung Disease cohort, were enrolled in this study. Plasma IL-33 levels were measured by enzyme-linked immunosorbent assay. We analyzed the association between IL-33 level and other clinical characteristics related to COPD. We also examined the features of patients with COPD who exhibited high IL-33 levels. Results: IL-33 levels varied, but were very low in most patients. Eosinophil count was significantly correlated with a plasma IL-33 level. In addition, old age and current smoking were related to a low IL-33 level. Significantly more patients with a higher IL-33 level had chronic bronchitis compared with those with a low IL-33 level. Conclusion: Plasma IL-33 level in patients with stable COPD was related to eosinophil count and chronic bronchitis phenotype. Further studies are needed to identify the precise mechanisms of IL-33/ST2 pathway in patients with COPD. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Dove Medical Press Ltd | - |
dc.title | Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease | - |
dc.type | Article | - |
dc.publisher.location | 뉴질랜드 | - |
dc.identifier.doi | 10.2147/COPD.S120445 | - |
dc.identifier.scopusid | 2-s2.0-85013224825 | - |
dc.identifier.wosid | 000392320600001 | - |
dc.identifier.bibliographicCitation | International Journal of COPD, v.12, pp 395 - 402 | - |
dc.citation.title | International Journal of COPD | - |
dc.citation.volume | 12 | - |
dc.citation.startPage | 395 | - |
dc.citation.endPage | 402 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | COMPUTED-TOMOGRAPHY | - |
dc.subject.keywordPlus | LUNG-DISEASE | - |
dc.subject.keywordPlus | AIRWAY INFLAMMATION | - |
dc.subject.keywordPlus | EMPHYSEMA | - |
dc.subject.keywordPlus | MICE | - |
dc.subject.keywordPlus | PHENOTYPES | - |
dc.subject.keywordPlus | BIOMARKER | - |
dc.subject.keywordPlus | ASTHMA | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | COPD | - |
dc.subject.keywordAuthor | biomarker | - |
dc.subject.keywordAuthor | cytokine | - |
dc.subject.keywordAuthor | interleukin-33 | - |
dc.subject.keywordAuthor | eosinophil | - |
dc.subject.keywordAuthor | pathogenesis | - |
dc.subject.keywordAuthor | chronic bronchitis | - |
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