Alterations of Macrophage Migration Inhibitory Factor Expression in the Nervous System of the Rat Cystitis Model
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Kwang Woo | - |
dc.contributor.author | Kim, Woong Bin | - |
dc.contributor.author | Lee, Sang Wook | - |
dc.contributor.author | Kim, Jae Heon | - |
dc.contributor.author | Kim, Jun Mo | - |
dc.contributor.author | Kim, Young Ho | - |
dc.contributor.author | Kim, Min Eui | - |
dc.date.accessioned | 2021-08-11T16:24:29Z | - |
dc.date.available | 2021-08-11T16:24:29Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0042-1138 | - |
dc.identifier.issn | 1423-0399 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8451 | - |
dc.description.abstract | Objective: We evaluated the changes in the migration inhibitory factor (MIF) expression with time in the bladder and spinal cord of a Sprague-Dawley rat cystitis model. Methods: The bladder created by injecting lipopolysaccharide (LPS) and the lumbosacral spinal cord were removed at 4, 24, and 48 h, and 7 days after the induction of chronic cystitis, and 24 h after the induction of acute cystitis. The MIF expression was estimated using immunohistochemic al staining, and the MIF mRNA was quantitatively analyzed using real-time polymerase chain reaction. Results: The MIF expression in the urothelial cell was lowest at 24 h after LPS injection. As the degree of inflammation decreased, the MIF expression in the urothelial cell gradually increased 48 h and 7 days. The quantitative analysis of the MIF mRNA showed that the MIF expression was highest in both the bladder and the lumbo-sacral spinal cord 24 h after the cystitis became most severe. In chronic cystitis, the MIF mRNA expressions in the bladder and the lumbosacral spinal cord were 2.8 and 2.1 times significantly higher than in the normal control. Conclusion: MIF is involved in urinary symptoms and pain in cystitis, and in the mechanism that prolongs the symptoms of chronic cystitis by involving bladder tissue, and the nervous system. (C) 2017 S. Karger AG, Basel | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | S. Karger AG | - |
dc.title | Alterations of Macrophage Migration Inhibitory Factor Expression in the Nervous System of the Rat Cystitis Model | - |
dc.type | Article | - |
dc.publisher.location | 스위스 | - |
dc.identifier.doi | 10.1159/000456077 | - |
dc.identifier.scopusid | 2-s2.0-85011831999 | - |
dc.identifier.wosid | 000396797800016 | - |
dc.identifier.bibliographicCitation | Urologia Internationalis, v.98, no.2, pp 228 - 235 | - |
dc.citation.title | Urologia Internationalis | - |
dc.citation.volume | 98 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 228 | - |
dc.citation.endPage | 235 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | SUBSTANCE-P | - |
dc.subject.keywordPlus | FACTOR MIF | - |
dc.subject.keywordPlus | BLADDER | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | MODULATOR | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CD44 | - |
dc.subject.keywordAuthor | Cystitis | - |
dc.subject.keywordAuthor | Bladder | - |
dc.subject.keywordAuthor | Migration inhibitory factor | - |
dc.subject.keywordAuthor | Pain | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.