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A new duet in cancer biology: AMPK the typical and UBE2O the atypical
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Vila, Isabelle K. | - |
| dc.contributor.author | Song, Su Jung | - |
| dc.contributor.author | Song, Min Sup | - |
| dc.date.accessioned | 2021-08-11T16:24:31Z | - |
| dc.date.available | 2021-08-11T16:24:31Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.issn | 2372-3556 | - |
| dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8458 | - |
| dc.description.abstract | Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1-hypoxia-inducible factor 1-alpha pathway. Critically, UBE2O targets adenosine monophosphate (AMP)-activated protein kinase-alpha 2 (AMPK alpha 2) for ubiquitination and degradation. We thus suggest the UBE2O-AMPK alpha 2 axis as a potential therapeutic target for cancer. | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.publisher | TAYLOR & FRANCIS INC | - |
| dc.title | A new duet in cancer biology: AMPK the typical and UBE2O the atypical | - |
| dc.type | Article | - |
| dc.publisher.location | 미국 | - |
| dc.identifier.doi | 10.1080/23723556.2017.1304846 | - |
| dc.identifier.scopusid | 2-s2.0-85050392070 | - |
| dc.identifier.wosid | 000406851400001 | - |
| dc.identifier.bibliographicCitation | MOLECULAR & CELLULAR ONCOLOGY, v.4, no.3 | - |
| dc.citation.title | MOLECULAR & CELLULAR ONCOLOGY | - |
| dc.citation.volume | 4 | - |
| dc.citation.number | 3 | - |
| dc.type.docType | Editorial Material | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.description.journalRegisteredClass | esci | - |
| dc.relation.journalResearchArea | Oncology | - |
| dc.relation.journalWebOfScienceCategory | Oncology | - |
| dc.subject.keywordPlus | TUMOR-SUPPRESSOR | - |
| dc.subject.keywordPlus | UBIQUITINATION | - |
| dc.subject.keywordAuthor | AMPK | - |
| dc.subject.keywordAuthor | AMPK alpha 2 | - |
| dc.subject.keywordAuthor | arsenite | - |
| dc.subject.keywordAuthor | breast cancer | - |
| dc.subject.keywordAuthor | cancer metabolism | - |
| dc.subject.keywordAuthor | HIF1 alpha | - |
| dc.subject.keywordAuthor | mTOR | - |
| dc.subject.keywordAuthor | prostate cancer | - |
| dc.subject.keywordAuthor | UBE2O | - |
| dc.subject.keywordAuthor | ubiquitination | - |
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Related Researcher
- SONG, SU JUNG
- College of Medicine (Department of Biochemistry)