Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats
DC Field | Value | Language |
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dc.contributor.author | Lee, Min Jung | - |
dc.contributor.author | Jang, Minhee | - |
dc.contributor.author | Bae, Chun-Sik | - |
dc.contributor.author | Park, Kyoung-Sun | - |
dc.contributor.author | Kim, Hak-Jae | - |
dc.contributor.author | Lee, Sanghyun | - |
dc.contributor.author | Lee, Sang Won | - |
dc.contributor.author | Kim, Young Ock | - |
dc.contributor.author | Cho, Ik-Hyun | - |
dc.date.accessioned | 2021-08-11T16:44:14Z | - |
dc.date.available | 2021-08-11T16:44:14Z | - |
dc.date.issued | 2016-12 | - |
dc.identifier.issn | 1549-1684 | - |
dc.identifier.issn | 1557-8577 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8578 | - |
dc.description.abstract | A traditional herbal prescription Kyung-Ok-Ko (KOK), composed of Rehmannia glutinosa Liboschitz var. purpurae, Lycium chinense, Aquilaria agallocha, Poria cocos, Panax ginseng, and honey, has been widely used in Oriental medicine as an invigorant for age-related diseases, such as amnesia and stroke. However, the beneficial value of KOK on uterine dysfunction related to hyperandrogenism is largely unknown. We investigated the effect of KOK (2.0 g/kg/day, per os) on endometrial abnormalities in a dehydroepiandrosterone (DHEA, subcutaneous)-induced polycystic ovary syndrome (PCOS) rat model. Preadministration of KOK significantly (p < 0.05) decreased the elevated body weight, uterus weight, and endometrial thickness by PCOS induction, corresponding to reduced apoptosis and the infiltration of immune cells (CD4(+) T cells, CD8(+) T cells, and macrophages) in the endometrium. These results were associated with reduced mRNA expression of interleukin (IL)-1 beta, IL-6, IL-8, and matrix metalloproteinase-3 and increased mRNA expression of IGF-beta 1, transforming growth factor (TGF)-beta, TGF-beta 1, and vascular endothelial growth factor in the uterus after DHEA injection. These multiple effects of KOK may synergistically prevent the development of endometrial abnormalities in DHEA-induced hyperandrogenism via anti-inflammatory action, indicating that KOK has preventive and therapeutic potential for suppressing PCOS. | - |
dc.format.extent | 11 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Mary Ann Liebert Inc. | - |
dc.title | Effects of Oriental Medicine Kyung-Ok-Ko on Uterine Abnormality in Hyperandrogenized Rats | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1089/rej.2015.1787 | - |
dc.identifier.scopusid | 2-s2.0-85007038280 | - |
dc.identifier.wosid | 000391834700003 | - |
dc.identifier.bibliographicCitation | Rejuvenation Research, v.19, no.6, pp 456 - 466 | - |
dc.citation.title | Rejuvenation Research | - |
dc.citation.volume | 19 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 456 | - |
dc.citation.endPage | 466 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Geriatrics & Gerontology | - |
dc.relation.journalWebOfScienceCategory | Geriatrics & Gerontology | - |
dc.subject.keywordPlus | POLYCYSTIC-OVARY-SYNDROME | - |
dc.subject.keywordPlus | DRIED REHMANNIAE RADIX | - |
dc.subject.keywordPlus | SYNDROME PCOS | - |
dc.subject.keywordPlus | ENDOMETRIAL HYPERPLASIA | - |
dc.subject.keywordPlus | PANAX-GINSENG | - |
dc.subject.keywordPlus | BALB/C MICE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | CANCER | - |
dc.subject.keywordPlus | METFORMIN | - |
dc.subject.keywordPlus | EXTRACT | - |
dc.subject.keywordAuthor | Kyung-Ok-Ko | - |
dc.subject.keywordAuthor | dehydroepiandrosterone | - |
dc.subject.keywordAuthor | endometrial abnormality | - |
dc.subject.keywordAuthor | polycystic ovary syndrome | - |
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