Augmenting invitro osteogenesis of a glycine-arginine-glycine-aspartic-conjugated oxidized alginate-gelatin-biphasic calcium phosphate hydrogel composite and invivo bone biogenesis through stem cell delivery
DC Field | Value | Language |
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dc.contributor.author | Linh, Nguyen T. B. | - |
dc.contributor.author | Paul, Kallyanashis | - |
dc.contributor.author | Kim, Boram | - |
dc.contributor.author | Lee, Byong-Taek | - |
dc.date.accessioned | 2021-08-11T16:44:50Z | - |
dc.date.available | 2021-08-11T16:44:50Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0885-3282 | - |
dc.identifier.issn | 1530-8022 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8641 | - |
dc.description.abstract | A functionally modified peptide-conjugated hydrogel system was fabricated with oxidized alginate/gelatin loaded with biphasic calcium phosphate to improve its biocompatibility and functionality. Sodium alginate was treated by controlled oxidation to transform the cis-diol group into an aldehyde group in a controlled manner, which was then conjugated to the amine terminus of glycine-arginine-glycine-aspartic. Oxidized alginate glycine-arginine-glycine-aspartic was then combined with gelatin-loaded biphasic calcium phosphate to form a hydrogel of composite oxidized alginate/gelatin/biphasic calcium phosphate that displayed enhanced human adipose stem cell adhesion, spreading and differentiation. H-1 nuclear magnetic resonance and electron spectroscopy for chemical analysis confirmed that the glycine-arginine-glycine-aspartic was successfully grafted to the oxidized alginate. Co-delivery of glycine-arginine-glycine-aspartic and human adipose stem cell in a hydrogel matrix was studied with the results indicating that hydrogel incorporated modified with glycine-arginine-glycine-aspartic and seeded with human adipose stem cell enhanced osteogenesis invitro and bone formation invivo. | - |
dc.format.extent | 13 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SAGE Publications | - |
dc.title | Augmenting invitro osteogenesis of a glycine-arginine-glycine-aspartic-conjugated oxidized alginate-gelatin-biphasic calcium phosphate hydrogel composite and invivo bone biogenesis through stem cell delivery | - |
dc.type | Article | - |
dc.publisher.location | 영국 | - |
dc.identifier.doi | 10.1177/0885328216667633 | - |
dc.identifier.scopusid | 2-s2.0-84994097620 | - |
dc.identifier.wosid | 000386976700004 | - |
dc.identifier.bibliographicCitation | Journal of Biomaterials Applications, v.31, no.5, pp 661 - 673 | - |
dc.citation.title | Journal of Biomaterials Applications | - |
dc.citation.volume | 31 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 661 | - |
dc.citation.endPage | 673 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | PEPTIDE | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | MICROSTRUCTURE | - |
dc.subject.keywordPlus | BIOMATERIALS | - |
dc.subject.keywordPlus | REGENERATION | - |
dc.subject.keywordPlus | FABRICATION | - |
dc.subject.keywordPlus | CONSTRUCTS | - |
dc.subject.keywordPlus | SCAFFOLDS | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordAuthor | Glycine-arginine-glycine-aspartic | - |
dc.subject.keywordAuthor | human adipose stem cell | - |
dc.subject.keywordAuthor | osteogenesis | - |
dc.subject.keywordAuthor | bone formation | - |
dc.subject.keywordAuthor | biphasic calcium phosphate | - |
dc.subject.keywordAuthor | oxidized alginate | - |
dc.subject.keywordAuthor | gelatin | - |
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