HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption
DC Field | Value | Language |
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dc.contributor.author | Moon, Jangsup | - |
dc.contributor.author | Kim, Tae-Joon | - |
dc.contributor.author | Lim, Jung-Ah | - |
dc.contributor.author | Sunwoo, Jun-Sang | - |
dc.contributor.author | Byun, Jung-Ick | - |
dc.contributor.author | Lee, Soon-Tae | - |
dc.contributor.author | Jung, Keun-Hwa | - |
dc.contributor.author | Park, Kyung-Il | - |
dc.contributor.author | Jung, Ki-Young | - |
dc.contributor.author | Jeon, Daejong | - |
dc.contributor.author | Yu, Kyung-Sang | - |
dc.contributor.author | Jang, In-Jin | - |
dc.contributor.author | Chu, Kon | - |
dc.contributor.author | Lee, Sang Kun | - |
dc.date.accessioned | 2021-08-11T16:45:08Z | - |
dc.date.available | 2021-08-11T16:45:08Z | - |
dc.date.issued | 2016-11 | - |
dc.identifier.issn | 0013-9580 | - |
dc.identifier.issn | 1528-1167 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8662 | - |
dc.description.abstract | ObjectiveOxcarbazepine (OXC) is a widely used antiepileptic drug for the treatment of partial seizures that was developed through structural variation of carbamazepine. Although OXC has a lower risk of cutaneous adverse drug reactions (cADRs) than carbamazepine, cADRs ranging from maculopapular eruption (MPE) to the more severe Stevens-Johnson syndrome and toxic epidermal necrolysis still limit the use of OXC in some patients. A few human leukocyte antigen (HLA)-related genetic risk factors for carbamazepine-induced cADRs have been identified. However, the HLA-related genetic risk factors associated with OXC-induced cADRs are unknown. MethodsA total of 40 patients who experienced OXC-induced MPE and 70 patients who were tolerant to OXC treatment were included in the study. Genomic DNA was extracted from the peripheral blood of these patients, and high-resolution HLA genotyping was performed. ResultsThe HLA-B*40:02 and HLA-DRB1*04:03 alleles were significantly associated with OXC-induced MPE compared with the OXC-tolerant group (odds ratio [OR] 4.33, p = 0.018 and OR 14.64, p = 0.003, respectively) and the general Korean population (OR 4.04, p = 0.001 and OR 3.11, p = 0.019, respectively). The HLA-B*15:01 genetic frequency was significantly lower in the OXC-MPE group compared to the OXC-tolerant group (OR 0.18, p = 0.016) and the Korean population (OR 0.22, p = 0.030). The allele frequencies of well-known HLA-related risk factors for carbamazepine-induced cADRs (HLA-B*15:02, A*31:01 and B*15:11) were not different among the three groups. SignificanceThis study is the first to demonstrate an association of HLA-B*40:02 and HLA-DRB1*04:03 with OXC hypersensitivity using a large cohort of patients with OXC-induced MPE. These findings should be confirmed in future studies in different ethnic groups. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | HLA-B*40:02 and DRB1*04:03 are risk factors for oxcarbazepine-induced maculopapular eruption | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/epi.13566 | - |
dc.identifier.scopusid | 2-s2.0-84988850530 | - |
dc.identifier.wosid | 000387652200018 | - |
dc.identifier.bibliographicCitation | Epilepsia, v.57, no.11, pp 1879 - 1886 | - |
dc.citation.title | Epilepsia | - |
dc.citation.volume | 57 | - |
dc.citation.number | 11 | - |
dc.citation.startPage | 1879 | - |
dc.citation.endPage | 1886 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.subject.keywordPlus | STEVENS-JOHNSON SYNDROME | - |
dc.subject.keywordPlus | TOXIC EPIDERMAL NECROLYSIS | - |
dc.subject.keywordPlus | CUTANEOUS ADVERSE-REACTIONS | - |
dc.subject.keywordPlus | JAPANESE PATIENTS | - |
dc.subject.keywordPlus | HAN CHINESE | - |
dc.subject.keywordPlus | KOREAN POPULATION | - |
dc.subject.keywordPlus | PARTIAL SEIZURES | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | HLA-B | - |
dc.subject.keywordPlus | CARBAMAZEPINE | - |
dc.subject.keywordAuthor | Oxcarbazepine | - |
dc.subject.keywordAuthor | Maculopapular eruption | - |
dc.subject.keywordAuthor | Human leukocyte antigen | - |
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