Suppression of Toll-Like Receptor 4 Dimerization by 1-[5-Methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine
DC Field | Value | Language |
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dc.contributor.author | Ahn, Sang-Il | - |
dc.contributor.author | Kim, Ji-Soo | - |
dc.contributor.author | Gu, Gyo-Jeong | - |
dc.contributor.author | Shin, Hyeon-Myeong | - |
dc.contributor.author | Kim, Ah-Yeon | - |
dc.contributor.author | Shim, Hyun-Jin | - |
dc.contributor.author | Kim, Yeon Joo | - |
dc.contributor.author | Koh, Kwang Oh | - |
dc.contributor.author | Mang, Joo Yang | - |
dc.contributor.author | Kim, Dae Young | - |
dc.contributor.author | Youn, Hyung-Sun | - |
dc.date.accessioned | 2021-08-11T16:46:23Z | - |
dc.date.available | 2021-08-11T16:46:23Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0365-6233 | - |
dc.identifier.issn | 1521-4184 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8725 | - |
dc.description.abstract | Toll-like receptor 4 (TLR4) recognizes lipopolysaccharide (LPS) and triggers the activation of myeloid differention factor 88 (MyD88) and the Toll/interleukin-1 receptor domain-containing adapter, inducing interferon- (TRIF)-dependent major downstream signaling pathways. To evaluate the therapeutic potential of 1-[5-methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine (MNP), previously synthesized in our laboratory, its effect on signal transduction via the TLR signaling pathways was examined. Here, we investigated whether MNP modulates the TLR4 signaling pathways and which anti-inflammatory target in TLR4 signaling is regulated by MNP. MNP inhibited the activation of nuclear factor-B (NF-B) induced by LPS (TLR4 agonist), and it also inhibited the expression of cyclooxygenase-2 and inducible nitric oxide synthase. MNP inhibited LPS-induced NF-B activation by targeting TLR4 dimerization in addition to IKK. These results suggest that MNP can modulate the TLR4 signaling pathway at the receptor level to decrease inflammatory gene expression. | - |
dc.format.extent | 6 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | John Wiley & Sons Ltd. | - |
dc.title | Suppression of Toll-Like Receptor 4 Dimerization by 1-[5-Methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine | - |
dc.type | Article | - |
dc.publisher.location | 독일 | - |
dc.identifier.doi | 10.1002/ardp.201600159 | - |
dc.identifier.scopusid | 2-s2.0-84989955440 | - |
dc.identifier.wosid | 000385667000003 | - |
dc.identifier.bibliographicCitation | Archiv der Pharmazie, v.349, no.10, pp 785 - 790 | - |
dc.citation.title | Archiv der Pharmazie | - |
dc.citation.volume | 349 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 785 | - |
dc.citation.endPage | 790 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SESQUITERPENE LACTONES | - |
dc.subject.keywordPlus | INNATE IMMUNITY | - |
dc.subject.keywordPlus | HOMODIMERIZATION | - |
dc.subject.keywordPlus | TRANSCRIPTION | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | KINASE | - |
dc.subject.keywordPlus | TLR4 | - |
dc.subject.keywordAuthor | 1-[5-Methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine | - |
dc.subject.keywordAuthor | Inflammation | - |
dc.subject.keywordAuthor | Lipopolysaccharide | - |
dc.subject.keywordAuthor | NF-B | - |
dc.subject.keywordAuthor | Toll-like receptor | - |
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