Fluoroquinolone resistance of Streptococcus pneumoniae isolates causing invasive disease: special focus on zabofloxacin
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Tark | - |
dc.contributor.author | Park, Su-Jin | - |
dc.contributor.author | Chong, Yong Pil | - |
dc.contributor.author | Park, Ki-Ho | - |
dc.contributor.author | Lee, Yu-Mi | - |
dc.contributor.author | Hong, Hyo-Lim | - |
dc.contributor.author | Kim, Hee Seung | - |
dc.contributor.author | Kim, Eun Sil | - |
dc.contributor.author | Lee, Sungkyoung | - |
dc.contributor.author | Choi, Dong Rack | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.contributor.author | Jeong, Jin-Yong | - |
dc.contributor.author | Lee, Sang-Oh | - |
dc.contributor.author | Choi, Sang-Ho | - |
dc.contributor.author | Woo, Jun Hee | - |
dc.contributor.author | Kim, Yang Soo | - |
dc.date.accessioned | 2021-08-11T16:46:27Z | - |
dc.date.available | 2021-08-11T16:46:27Z | - |
dc.date.issued | 2016-10 | - |
dc.identifier.issn | 0732-8893 | - |
dc.identifier.issn | 1879-0070 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8731 | - |
dc.description.abstract | The present study examined the in vitro activity of various antibiotics including zabofloxacin, against isolates responsible for invasive pneumococcal diseases. Between 1997 and 2008, a total of 208 isolates were collected from sterile fluids, including blood (n = 196, 94.2%), pleural fluid (n = 5, 2.4%), cerebrospinal fluid (n = 5, 2.4%), and ascites (n = 2, 1.0%). Zabofloxacin showed the lowest MIC50 (0.015 mu g/mL) and MIC50 (0.025 mu g/mL) values of all the tested antibiotics. Rates of isolates resistant to penicillin (MIC >= ng/mL), ceftriaxone (MIC >= 4 mu g/mL) and levofloxacin (MIC >= 8 mu g/mL) were 3.4%, 0.4% and 2.0%, respectively. Four isolates (2.0%) were resistant to levofloxacin, and zabofloxacin showed low MICs (range, 0.025-0.125 mu g/mL). Zabofloxacin shows potent in vitro activity against S. pneumoniae isolates that caused invasive disease, even strains that are resistant to levofloxacin. (C) 2016 Published by Elsevier Inc. | - |
dc.format.extent | 3 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Elsevier BV | - |
dc.title | Fluoroquinolone resistance of Streptococcus pneumoniae isolates causing invasive disease: special focus on zabofloxacin | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1016/j.diagmicrobio.2016.07.019 | - |
dc.identifier.scopusid | 2-s2.0-84989932701 | - |
dc.identifier.wosid | 000384395400014 | - |
dc.identifier.bibliographicCitation | Diagnostic Microbiology and Infectious Disease, v.86, no.2, pp 181 - 183 | - |
dc.citation.title | Diagnostic Microbiology and Infectious Disease | - |
dc.citation.volume | 86 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 183 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | UNITED-STATES | - |
dc.subject.keywordPlus | INCREASING PREVALENCE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | SUSCEPTIBILITY | - |
dc.subject.keywordPlus | DW-224A | - |
dc.subject.keywordPlus | CANADA | - |
dc.subject.keywordPlus | AGENTS | - |
dc.subject.keywordAuthor | Streptococcus pneumoniae | - |
dc.subject.keywordAuthor | Zabofloxacin | - |
dc.subject.keywordAuthor | Invasive | - |
dc.subject.keywordAuthor | Resistance | - |
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