The protective role of phytochemicals on TiO2 nanoparticles-induced DNA damage in lymphocytes
DC Field | Value | Language |
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dc.contributor.author | Ryu, A-Reum | - |
dc.contributor.author | Bang, In-Chul | - |
dc.contributor.author | Lee, Seong-A | - |
dc.contributor.author | Lee, Mi-Young | - |
dc.date.accessioned | 2021-08-11T17:24:06Z | - |
dc.date.available | 2021-08-11T17:24:06Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0254-8704 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8809 | - |
dc.description.abstract | The adverse health effect of nanoparticles is of concern for humans and environment. In the present study, TiO2-nanoparticles (TiO2-NPs)-induced oxidative DNA damage in lymphocytes was measured by comet assay. 80 mu g ml(-1) TiO2-NPs induced approximately 3-fold increase in DNA damage than in the PBS-control group as measured by olive tail moment. However, on treating vitamin C and N-acetylcysteine, DNA damage was effectively protected in a concentration dependent manner. Moreover, the protective effect of several phytochemicals including berberine, resveratrol, sulforaphane, and curcumin on DNA damage caused by TiO2-NPs was manifested. The increased olive tail moment induced by TiO2-NPs was effectively inhibited by treatment with these phytochemicals. Especially, olive tail moment of 5 mu g ml(-1) berberine-treated group was significantly reduced down to the level of control group, showing almost complete protection. Taken together, the protective effect of phytochemicals against DNA damage by TiO2-NPs may be applied for the development of antidote for TiO2 toxicity. | - |
dc.format.extent | 5 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Academy of Environmental Biology | - |
dc.title | The protective role of phytochemicals on TiO2 nanoparticles-induced DNA damage in lymphocytes | - |
dc.type | Article | - |
dc.publisher.location | 인도 | - |
dc.identifier.scopusid | 2-s2.0-84989813212 | - |
dc.identifier.wosid | 000383311800008 | - |
dc.identifier.bibliographicCitation | Journal of Environmental Biology, v.37, no.5, pp 913 - 917 | - |
dc.citation.title | Journal of Environmental Biology | - |
dc.citation.volume | 37 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 913 | - |
dc.citation.endPage | 917 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Environmental Sciences & Ecology | - |
dc.relation.journalWebOfScienceCategory | Environmental Sciences | - |
dc.subject.keywordPlus | TITANIUM-DIOXIDE NANOPARTICLES | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | BERBERINE | - |
dc.subject.keywordPlus | ANTIOXIDANTS | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.subject.keywordAuthor | Comet assay | - |
dc.subject.keywordAuthor | DNA damage | - |
dc.subject.keywordAuthor | Lymphocyte | - |
dc.subject.keywordAuthor | Phytochemical | - |
dc.subject.keywordAuthor | TiO2-nanoparticles | - |
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