Seven low-mass ions in pretreatment serum as potential predictive markers of the chemoradiotherapy response of rectal cancer
DC Field | Value | Language |
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dc.contributor.author | Roh, Kangsan | - |
dc.contributor.author | Yeo, Seung-Gu | - |
dc.contributor.author | Yoo, Byong Chul | - |
dc.contributor.author | Kim, Kyung-Hee | - |
dc.contributor.author | Kim, Sun Young | - |
dc.contributor.author | Kim, Min-Jeong | - |
dc.date.accessioned | 2021-08-11T17:24:11Z | - |
dc.date.available | 2021-08-11T17:24:11Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0959-4973 | - |
dc.identifier.issn | 1473-5741 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8819 | - |
dc.description.abstract | Preoperative chemoradiotherapy (CRT) is generally performed for locally advanced rectal cancer (LARC, cStage 2 or 3) to improve local disease control and patient survival. The pathological tumor response to CRT is a surrogate marker that is associated with oncological outcome. Thus, markers that predict the response to CRT would be valuable for individualizing treatment for LARC patients. The current study used metabolomics-based approaches to identify molecular markers that predict the response to CRT. Seventy-six patients with LARC who received pelvic radiotherapy and concurrent chemotherapy using tegafururacil and leucovorin were enrolled. Radical surgery was performed 6-8 weeks after the completion of CRT. The postsurgical pathological CRT response was evaluated using the ypStage or tumor regression grade. Profiling patterns of low-mass ions (LMIs) in the pretreatment sera were obtained from all patients using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Our previously developed two-step algorithms, which showed a powerful diagnostic capability during colorectal cancer screening, were then used to screen for meaningful LMIs with discriminatory power. One combination consisting of seven LMIs was identified, whose discriminatory score separated a good CRT response (ypStage 0-1) from a poor CRT response (ypStage 3-4) successfully. However, each individual LMI alone showed insignificant discriminatory power. This finding suggests that analysis of the LMIs in pretreatment serum could serve as a predictive marker of the CRT response in patients with LARC. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved. | - |
dc.format.extent | 7 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Seven low-mass ions in pretreatment serum as potential predictive markers of the chemoradiotherapy response of rectal cancer | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1097/CAD.0000000000000391 | - |
dc.identifier.scopusid | 2-s2.0-84973375167 | - |
dc.identifier.wosid | 000380811300011 | - |
dc.identifier.bibliographicCitation | Anti-Cancer Drugs, v.27, no.8, pp 787 - 793 | - |
dc.citation.title | Anti-Cancer Drugs | - |
dc.citation.volume | 27 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 787 | - |
dc.citation.endPage | 793 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | PREOPERATIVE CHEMORADIOTHERAPY | - |
dc.subject.keywordPlus | URACIL | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | TEGAFUR | - |
dc.subject.keywordAuthor | chemoradiotherapy | - |
dc.subject.keywordAuthor | low-mass ions | - |
dc.subject.keywordAuthor | metabolite | - |
dc.subject.keywordAuthor | rectal neoplasms | - |
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