Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke Clopidogrel Plus Aspirin Versus Aspirin Alone
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Keun-Sik | - |
dc.contributor.author | Lee, Seung-Hoon | - |
dc.contributor.author | Kim, Eung Gyu | - |
dc.contributor.author | Cho, Ki-Hyun | - |
dc.contributor.author | Chang, Dae Il | - |
dc.contributor.author | Rha, Joung-Ho | - |
dc.contributor.author | Bae, Hee-Joon | - |
dc.contributor.author | Lee, Kyung Bok | - |
dc.contributor.author | Kim, Dong Eog | - |
dc.contributor.author | Park, Jong-Moo | - |
dc.contributor.author | Kim, Hahn-Young | - |
dc.contributor.author | Cha, Jae-Kwan | - |
dc.contributor.author | Yu, Kyung-Ho | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Lee, Soo Joo | - |
dc.contributor.author | Choi, Jay Chol | - |
dc.contributor.author | Cho, Yong-Jin | - |
dc.contributor.author | Kwon, Sun U. | - |
dc.contributor.author | Kim, Gyeong-Moon | - |
dc.contributor.author | Sohn, Sung-Il | - |
dc.contributor.author | Park, Kwang-Yeol | - |
dc.contributor.author | Kang, Dong-Wha | - |
dc.contributor.author | Sohn, Chul-Ho | - |
dc.contributor.author | Lee, Jun | - |
dc.contributor.author | Yoon, Byung-Woo | - |
dc.date.accessioned | 2021-08-11T17:24:13Z | - |
dc.date.available | 2021-08-11T17:24:13Z | - |
dc.date.issued | 2016-09 | - |
dc.identifier.issn | 0039-2499 | - |
dc.identifier.issn | 1524-4628 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8822 | - |
dc.description.abstract | Background and Purpose In patients with acute ischemic stroke caused by large artery atherosclerosis, clopidogrel plus aspirin versus aspirin alone might be more effective to prevent recurrent cerebral ischemia. However, there is no clear evidence. Methods In this multicenter, double-blind, placebo-controlled trial, we randomized 358 patients with acute ischemic stroke of presumed large artery atherosclerosis origin within 48 hours of onset to clopidogrel (75 mg/d without loading dose) plus aspirin (300-mg loading followed by 100 mg/d) or to aspirin alone (300-mg loading followed by 100 mg/d) for 30 days. The primary outcome was new symptomatic or asymptomatic ischemic lesion on magnetic resonance imaging within 30 days. Secondary outcomes were 30-day functional disability, clinical stroke recurrence, and composite of major vascular events. Safety outcome was any bleeding. Results Of 358 patients enrolled, 334 (167 in each group) completed follow-up magnetic resonance imaging. The 30-day new ischemic lesion recurrence rate was comparable between the clopidogrel plus aspirin and the aspirin monotherapy groups (36.5% versus 35.9%; relative risk, 1.02; 95% confidence interval, 0.77-1.35; P=0.91). Of the recurrent ischemic lesions, 94.2% were clinically asymptomatic. There were no differences in secondary outcomes between the 2 groups. Any bleeding were more frequent in the combination group than in the aspirin monotherapy group, but the difference was not significant (16.7% versus 10.7%; P=0.11). One hemorrhagic stroke occurred in the clopidogrel plus aspirin group. Conclusions Clopidogrel plus aspirin might not be superior to aspirin alone for preventing new ischemic lesion and clinical vascular events in patients with acute ischemic stroke caused by large artery atherosclerosis. | - |
dc.format.extent | 8 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Recurrent Ischemic Lesions After Acute Atherothrombotic Stroke Clopidogrel Plus Aspirin Versus Aspirin Alone | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1161/STROKEAHA.115.012293 | - |
dc.identifier.scopusid | 2-s2.0-84978711047 | - |
dc.identifier.wosid | 000383559300037 | - |
dc.identifier.bibliographicCitation | Stroke, v.47, no.9, pp 2323 - 2330 | - |
dc.citation.title | Stroke | - |
dc.citation.volume | 47 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 2323 | - |
dc.citation.endPage | 2330 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | INTRACRANIAL ARTERIAL-STENOSIS | - |
dc.subject.keywordPlus | MONO ANTIPLATELET THERAPY | - |
dc.subject.keywordPlus | ST-SEGMENT ELEVATION | - |
dc.subject.keywordPlus | MINOR STROKE | - |
dc.subject.keywordPlus | ATTACK | - |
dc.subject.keywordPlus | TRIAL | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | DIFFUSION | - |
dc.subject.keywordPlus | PROFILE | - |
dc.subject.keywordAuthor | antiplatelet drugs | - |
dc.subject.keywordAuthor | aspirin | - |
dc.subject.keywordAuthor | atherosclerosis | - |
dc.subject.keywordAuthor | clinical trial | - |
dc.subject.keywordAuthor | randomized | - |
dc.subject.keywordAuthor | clopidogrel | - |
dc.subject.keywordAuthor | recurrence | - |
dc.subject.keywordAuthor | stroke | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.