Early deterioration of residual hearing in patients with SLC26A4 mutations
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Bo Gyung | - |
dc.contributor.author | Roh, Kyung Jin | - |
dc.contributor.author | Park, Ah Young | - |
dc.contributor.author | Lee, Seung Chul | - |
dc.contributor.author | Kang, Bo Sung | - |
dc.contributor.author | Seo, Young Joon | - |
dc.contributor.author | Lee, Jong Dae | - |
dc.contributor.author | Choi, Jae Young | - |
dc.date.accessioned | 2021-08-11T17:24:57Z | - |
dc.date.available | 2021-08-11T17:24:57Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0023-852X | - |
dc.identifier.issn | 1531-4995 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8908 | - |
dc.description.abstract | Objectives/HypothesisTo compare changes in hearing in patients with SLC26A4 during early and late childhood. Study DesignRetrospective chart review. MethodsA total of 102 patients with biallelic SLC26A4 mutations visited the tertiary referral otolaryngology department between March 2005 and February 2015. Newborn hearing screening tests had been performed on 22 of these patients. We analyzed 26 patients who underwent hearing tests more than twice using the same method (auditory brainstem response/auditory steady state response/play audiometry) before and after 3 years of age. We analyzed changes in hearing levels according to age. ResultsAmong 22 patients with SLC26A4 mutations who underwent newborn hearing screening tests, seven (31.8%) passed the newborn hearing screening test in both ears, and six (27.3%) passed in one ear. Among 16 patients with SLC26A4 mutations who underwent hearing tests more than twice before age 3 years, the hearing levels of 14 (87.5%) deteriorated rapidly during this time. Among 16 patients with SLC26A4 mutations who underwent hearing tests more than twice after the age of 3 years, two (12.5%) patients' hearing levels deteriorated; the hearing levels of most of the patients were relatively stable. ConclusionsThese data suggest that many patients with SLC26A4 mutations have significant residual hearing at birth, and that the hearing deterioration in these patients occurs before 3 years of age. After age 3 years, the residual hearing was relatively stable and did not tend to deteriorate. Therefore, in patients with a pendrin mutation, early intervention to preserve residual hearing should be a clinical focus. | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Lippincott Williams & Wilkins Ltd. | - |
dc.title | Early deterioration of residual hearing in patients with SLC26A4 mutations | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1002/lary.25786 | - |
dc.identifier.scopusid | 2-s2.0-84978715256 | - |
dc.identifier.wosid | 000379984700004 | - |
dc.identifier.bibliographicCitation | Laryngoscope, v.126, no.8, pp E286 - E291 | - |
dc.citation.title | Laryngoscope | - |
dc.citation.volume | 126 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | E286 | - |
dc.citation.endPage | E291 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalResearchArea | Otorhinolaryngology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.relation.journalWebOfScienceCategory | Otorhinolaryngology | - |
dc.subject.keywordPlus | ENLARGED VESTIBULAR AQUEDUCT | - |
dc.subject.keywordPlus | PENDRED-SYNDROME | - |
dc.subject.keywordPlus | PDS MUTATIONS | - |
dc.subject.keywordPlus | MOUSE MODEL | - |
dc.subject.keywordPlus | DEAFNESS | - |
dc.subject.keywordPlus | SPECTRUM | - |
dc.subject.keywordPlus | CHILDREN | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | SLC26A4 | - |
dc.subject.keywordAuthor | mutation | - |
dc.subject.keywordAuthor | hearing | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(31538) 22, Soonchunhyang-ro, Asan-si, Chungcheongnam-do, Republic of Korea+82-41-530-1114
COPYRIGHT 2021 by SOONCHUNHYANG UNIVERSITY ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.