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Involvement of T cells in early evolving segmental vitiligo

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dc.contributor.authorShin, J.-
dc.contributor.authorKang, H. Y.-
dc.contributor.authorKim, K. H.-
dc.contributor.authorPark, C. J.-
dc.contributor.authorOh, S. H.-
dc.contributor.authorLee, S. C.-
dc.contributor.authorLee, S.-
dc.contributor.authorChoi, G. S.-
dc.contributor.authorHann, S. K.-
dc.date.accessioned2021-08-11T17:25:10Z-
dc.date.available2021-08-11T17:25:10Z-
dc.date.issued2016-08-
dc.identifier.issn0307-6938-
dc.identifier.issn1365-2230-
dc.identifier.urihttps://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8923-
dc.description.abstractRecent studies have suggested an overlapping autoimmune mechanism between segmental vitiligo (SV) and nonsegmental vitiligo (NSV). Although T-cell infiltration is observed in the margins of active lesions in NSV, the histopathological characteristics of the active margin of SV are not well known. To determine if T-cell inflammatory responses are present in the active margin of SV lesions, biopsies were taken from the active margin of a lesion in 12 patients with early or actively spreading SV and compared with a normal control sample (on the symmetrical, opposite site of the same dermatome). The samples were stained for CD4, CD8, CD25 and interferon-. Lymphocytic infiltration was seen in 70% of patients. CD4+ T cells infiltrated the dermis, while CD8+ T cells were present in the epidermis or attached to the basal layer. The increase in the number of CD8+ T cells was significant (P < 0.04), while CD4+ or CD25+ T cells also appeared to be increased in number, but this was not significant. These results suggest that SV also has an autoimmune mechanism in the early evolving stage.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherBlackwell Publishing Inc.-
dc.titleInvolvement of T cells in early evolving segmental vitiligo-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1111/ced.12852-
dc.identifier.scopusid2-s2.0-84978255394-
dc.identifier.wosid000380056400019-
dc.identifier.bibliographicCitationClinical and Experimental Dermatology, v.41, no.6, pp 671 - 674-
dc.citation.titleClinical and Experimental Dermatology-
dc.citation.volume41-
dc.citation.number6-
dc.citation.startPage671-
dc.citation.endPage674-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaDermatology-
dc.relation.journalWebOfScienceCategoryDermatology-
dc.subject.keywordAuthorInvolvement of T cells-
dc.subject.keywordAuthorevolving segmental vitiligo-
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