Involvement of T cells in early evolving segmental vitiligo
DC Field | Value | Language |
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dc.contributor.author | Shin, J. | - |
dc.contributor.author | Kang, H. Y. | - |
dc.contributor.author | Kim, K. H. | - |
dc.contributor.author | Park, C. J. | - |
dc.contributor.author | Oh, S. H. | - |
dc.contributor.author | Lee, S. C. | - |
dc.contributor.author | Lee, S. | - |
dc.contributor.author | Choi, G. S. | - |
dc.contributor.author | Hann, S. K. | - |
dc.date.accessioned | 2021-08-11T17:25:10Z | - |
dc.date.available | 2021-08-11T17:25:10Z | - |
dc.date.issued | 2016-08 | - |
dc.identifier.issn | 0307-6938 | - |
dc.identifier.issn | 1365-2230 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/sch/handle/2021.sw.sch/8923 | - |
dc.description.abstract | Recent studies have suggested an overlapping autoimmune mechanism between segmental vitiligo (SV) and nonsegmental vitiligo (NSV). Although T-cell infiltration is observed in the margins of active lesions in NSV, the histopathological characteristics of the active margin of SV are not well known. To determine if T-cell inflammatory responses are present in the active margin of SV lesions, biopsies were taken from the active margin of a lesion in 12 patients with early or actively spreading SV and compared with a normal control sample (on the symmetrical, opposite site of the same dermatome). The samples were stained for CD4, CD8, CD25 and interferon-. Lymphocytic infiltration was seen in 70% of patients. CD4+ T cells infiltrated the dermis, while CD8+ T cells were present in the epidermis or attached to the basal layer. The increase in the number of CD8+ T cells was significant (P < 0.04), while CD4+ or CD25+ T cells also appeared to be increased in number, but this was not significant. These results suggest that SV also has an autoimmune mechanism in the early evolving stage. | - |
dc.format.extent | 4 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | Blackwell Publishing Inc. | - |
dc.title | Involvement of T cells in early evolving segmental vitiligo | - |
dc.type | Article | - |
dc.publisher.location | 미국 | - |
dc.identifier.doi | 10.1111/ced.12852 | - |
dc.identifier.scopusid | 2-s2.0-84978255394 | - |
dc.identifier.wosid | 000380056400019 | - |
dc.identifier.bibliographicCitation | Clinical and Experimental Dermatology, v.41, no.6, pp 671 - 674 | - |
dc.citation.title | Clinical and Experimental Dermatology | - |
dc.citation.volume | 41 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 671 | - |
dc.citation.endPage | 674 | - |
dc.type.docType | Article | - |
dc.description.isOpenAccess | N | - |
dc.description.journalRegisteredClass | sci | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Dermatology | - |
dc.relation.journalWebOfScienceCategory | Dermatology | - |
dc.subject.keywordAuthor | Involvement of T cells | - |
dc.subject.keywordAuthor | evolving segmental vitiligo | - |
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